Cytokines Recombinant Proteins

Human IL 13 Recombinant Protein (RPPB0576)

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SKU:
RPPB0576
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P35225
Research Area:
Cytokines

Description

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Product Name:Human IL 13 Recombinant Protein
Product Code:RPPB0576
Size:10µg
Species:Human
Target:IL 13
Synonyms:NC30, ALRH, BHR1, P600, IL-13, MGC116786, MGC116788, MGC116789.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:Interleukin -13 His-Tag protein is supplied in 25mM Na-Acetate (pH 4.8) and 50% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.

Interleukin-13 is a pleiotropic regulatory cytokine, which shares many of the properties of Interleukin-4. IL-13 is produced primarily by activated T lymphocytes and acts via specific cell surface receptor complexes. Its biological activities include the stimulation of B-cell proliferation and differentiation and the regulation of inflammatory and immune responses.

Interleukin-13 His Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 112 amino acids fragment (21-132) having a molecular weight of 12.84kDa with a 4kDa amino-terminal hexahistidine tag (total weight of 16.84kDa). The IL-13 His is purified by proprietary chromatographic techniques.

UniProt Protein Function:IL13: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH). Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure. Belongs to the IL-4/IL-13 family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: extracellular region; extracellular space

Molecular Function:interleukin-13 receptor binding; protein binding

Biological Process: cell motility; cell-cell signaling; positive regulation of B cell proliferation; positive regulation of immunoglobulin production; positive regulation of macrophage activation; positive regulation of mast cell degranulation

Disease: Allergic Rhinitis; Asthma, Susceptibility To

NCBI Summary:This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
UniProt Code:P35225
NCBI GenInfo Identifier:239938644
NCBI Gene ID:3596
NCBI Accession:P35225.2
UniProt Secondary Accession:P35225,O43644, Q4VB52, Q9UDC7,
UniProt Related Accession:P35225
Molecular Weight:15,816 Da
NCBI Full Name:Interleukin-13
NCBI Synonym Full Names:interleukin 13
NCBI Official Symbol:IL13��
NCBI Official Synonym Symbols:P600; IL-13��
NCBI Protein Information:interleukin-13
UniProt Protein Name:Interleukin-13
Protein Family:Interleukin
UniProt Gene Name:IL13��
UniProt Entry Name:IL13_HUMAN
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