SCN3B (sodium channel; voltage-gated; type III; beta ;human IgG1-Fc chimera) belongs to the sodium channel auxiliary subunit SCN3B family. It contains a single Ig-like C2-type (immunoglobulin-like) domain. Voltage-gated sodium channels are transmembrane glycoprotein complexes made up of a large alpha subunit and one or more regulatory beta subunits. They are in charge of the creation and propagation of action potentials in neurons and muscles. The SCN3B gene codes for one member of the sodium channel beta subunit gene family and has an influence on the Sodium channel inactivation kinetics. Two alternatively spliced variants; encoding the same protein; have been identified. Brugada syndrome type 7 is caused by faults in SCN3B. A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram. This condition can lead to the ventricles beating too rapidly, preventing blood from circulating freely throughout the body. If a person's heart stops beating (ventricular fibrillation) and they haven't been resuscitated within minutes, they will faint and could die. Human IgG4-Fc Recombinant Protein (108 Ser/Pro) is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human IgG4-Fc Recombinant Protein (108 Ser/Pro) (RPES4834)
Product Code:
RPES4834
Size:
100µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
Ig gamma-4 chain C region,IgG4 Fc,IGHG4
Accession:
P01861
Sequence:
Glu 99-Lys 327; 108Ser/Pro
Fusion tag:
Endotoxin:
<1.0 EU per µg of the protein as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human IgG4 Fc region (P01861) (Glu 99-Lys 327; 108Ser/Pro) was expressed and purified.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
25.5 kDa
AP Mol Mass:
35 kDa
Formulation:
Lyophilized from sterile PBS; pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
