Human IgG1/Immunoglobulin heavy constant gamma 1 Polyclonal Antibody

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SKU:
CAB24654
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB

Description

Product Name:Human IgG1/Immunoglobulin heavy constant gamma 1 Polyclonal Antibody
Product Code:CAB24654
Reactivity:Human, Mouse
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:Human plasma, Mouse spleen
Cellular Location:Cell Membrane and Secreted

IgG is a monomeric immunoglobulin, built of two heavy chains gamma and two light chains. Each molecule has two antigen binding sites. This is the most abundant immunoglobulin and is approximately equally distributed in blood and in tissue liquids, constituting 75% of serum immunoglobulins in humans. This is the only isotype that can pass through the human placenta, thereby providing protection to the fetus in its first weeks of life before its own immune system has developed. It can bind to many kinds of pathogens, for example viruses, bacteria, and fungi, and protects the body against them by complement activation (classic pathway), opsonization for phagocytosis and neutralisation of their toxins. There are 4 subclasses: IgG1 (66%), IgG2 (23%), IgG3 (7%) and IgG4 (4%).

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 21-130 of human IgG1/Immunoglobulin heavy constant gamma 1(P01857).
Sequence:GTAAL GCLVK DYFPE PVTVS WNSGA LTSGV HTFPA VLQSS GLYSL SSVVT VPSSS LGTQT YICNV NHKPS NTKVD KKVEP KSCDK THTCP PCPAP ELLGG PSVFL FPPKP
Calculated MW:44kDa
Observed MW:55kDa/35kDa
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