Growth Factors & Cytokines Recombinant Proteins

Human IGFBP7 Recombinant Protein (RPPB0440)

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RPPB0440

Description

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Product Name:Human IGFBP7 Recombinant Protein
Product Code:RPPB0440
Size:10µg
Species:Human
Target:IGFBP7
Synonyms:Insulin-like growth factor-binding protein 7, IBP-7, IGF-binding protein 7, IGFBP-7, IGFBP-rP1, MAC25 protein, PGI2-stimulating factor, Prostacyclin-stimulating factor, Tumor-derived adhesion factor, TAF, IGFBP7, MAC25, PSF, AGM, FSTL2, RAMSVPS, IGFBP-7v, IGFBPRP1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:IGFBP7 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0),�0.2M NaCl, 50% glycerol, 2mM DTT and 1mM EDTA.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSSSSDTCG PCEPASCPPL PPLGCLLGET RDACGCCPMC ARGEGEPCGG GGAGRGYCAP GMECVKSRKR RKGKAGAAAG GPGVSGVCVC KSRYPVCGSD GTTYPSGCQL RAASQRAESR GEKAITQVSK GTCEQGPSIV TPPKDIWNVT GAQVYLSCEV IGIPTPVLIW NKVKRGHYGV QRTELLPGDR DNLAIQTRGG PEKHEVTGWV LVSPLSKEDA GEYECHASNS QGQASASAKI TVVDALHEIP VKKGEGAEL

Insulin-like Growth Factor-Binding Protein 7 (IGFBP7) is a member of the IGFBP family. IGFBP family members are all cysteine rich proteins with conserved cysteine and have an IGFBP domain, a Kazal-like domain and an Ig-like C2-type domain. IGFBP7 is expressed in a broad range of normal human tissues and it mostly shows reduced expression in cancer cell lines of prostate, breast, colon, and lung origin. IGFBP7 has a role in skeletal myogenesis by binding to IGF in a manner which inhibits IGF induced differentiation of skeletal myoblasts, without disturbing IGF induced proliferation. Moreover, IGFBP7 suppresses growth and colony formation of prostate and breast cancer cell lines via an IGF independent mechanism, which triggers a delay in the G1 phase of the cell cycle, and increased apoptosis.

IGFBP7 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 279 amino acids (27-282 a.a.) and having a molecular mass of 28.8kDa.IGFBP7 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.�

UniProt Protein Function:IGFBP7: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Defects in IGFBP7 are the cause of retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS). RAMSVPS is an autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction.
UniProt Protein Details:

Protein type:Cell cycle regulation; Cell adhesion; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q12

Cellular Component: extracellular matrix; extracellular space; extracellular region

Molecular Function:insulin-like growth factor binding; protein binding

Biological Process: negative regulation of cell proliferation; response to retinoic acid; response to cortisol stimulus; response to heat; regulation of steroid biosynthetic process; regulation of cell growth; cell adhesion; inner ear development; embryo implantation; cellular response to hormone stimulus

Disease: Retinal Arterial Macroaneurysm With Supravalvular Pulmonic Stenosis

NCBI Summary:This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]
UniProt Code:Q16270
NCBI GenInfo Identifier:23396609
NCBI Gene ID:3490
NCBI Accession:Q16270.1
UniProt Related Accession:Q16270
Molecular Weight:
NCBI Full Name:Insulin-like growth factor-binding protein 7
NCBI Synonym Full Names:insulin like growth factor binding protein 7
NCBI Official Symbol:IGFBP7��
NCBI Official Synonym Symbols:AGM; PSF; TAF; FSTL2; IBP-7; MAC25; IGFBP-7; RAMSVPS; IGFBP-7v; IGFBPRP1��
NCBI Protein Information:insulin-like growth factor-binding protein 7
UniProt Protein Name:Insulin-like growth factor-binding protein 7
UniProt Synonym Protein Names:IGFBP-rP1; MAC25 protein; PGI2-stimulating factor; Prostacyclin-stimulating factor; Tumor-derived adhesion factor; TAF
Protein Family:Insulin-like growth factor-binding protein
UniProt Gene Name:IGFBP7��
UniProt Entry Name:IBP7_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q16270
Research Area:
Growth Factors & Cytokines
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