Growth Factors & Cytokines Recombinant Proteins
Human IGFBP7 Recombinant Protein (RPPB0439)
- SKU:
- RPPB0439
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q16270
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Human IGFBP7 Recombinant Protein |
| Product Code: | RPPB0439 |
| Size: | 25µg |
| Species: | Human |
| Target: | IGFBP7 |
| Synonyms: | Insulin-like growth factor-binding protein 7, IBP-7, IGF-binding protein 7, IGFBP-7, IGFBP-rP1, MAC25 protein, PGI2-stimulating factor, Prostacyclin-stimulating factor, Tumor-derived adhesion factor, TAF, IGFBP7, MAC25, PSF, AGM, FSTL2, RAMSVPS, IGFBP-7v, IGFBPRP1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The IGFBP7 was lyophilized from a 0.2�m filtered concentrated solution in 20mM Tris-HCl, pH 8.5 and 150mM NaCl. |
| Solubility: | It is recommended to reconstitute the lyophilized IGFBP-7 in sterile 20mM AcOH (acetic Acid) not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized IGFBP7 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IGFBP-7 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 97.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | SSSDTCGPCE PASCPPLPPL GCLLGETRDA CGCCPMCARG EGEPCGGGGA GRGYCAPGME CVKSRKRRKG KAGAAAGGPG VSGVCVCKSR YPVCGSDGTT YPSGCQLRAA SQRAESRGEK AITQVSKGTC EQGPSIVTPP KDIWNVTGAQ VYLSCEVIGI PTPVLIWNKV KRGHYGVQRT ELLPGDRDNL AIQTRGGPEK HEVTGWVLVS PLSKEDAGEY ECHASNSQGQ ASASAKITVV DALHEIPVKK GEGAEL |
Insulin-like Growth Factor-Binding Protein 7 (IGFBP7) is a member of the IGFBP family. IGFBP family members are all cysteine rich proteins with conserved cysteine and have an IGFBP domain, a Kazal-like domain and an Ig-like C2-type domain. IGFBP7 is expressed in a broad range of normal human tissues and it mostly shows reduced expression in cancer cell lines of prostate, breast, colon, and lung origin. IGFBP7 has a role in skeletal myogenesis by binding to IGF in a manner which inhibits IGF induced differentiation of skeletal myoblasts, without disturbing IGF induced proliferation. Moreover, IGFBP7 suppresses growth and colony formation of prostate and breast cancer cell lines via an IGF independent mechanism, which triggers a delay in the G1 phase of the cell cycle, and increased apoptosis.
Recombinant Human IGFBP7 produced in E.coli cells is a non-glycosylated, homodimeric protein containing 2x256 amino acid chains and having a molecular mass of 26.4kDa. The IGFBP-7 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IGFBP7: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Defects in IGFBP7 are the cause of retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS). RAMSVPS is an autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Cell adhesion; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 4q12 Cellular Component: extracellular matrix; extracellular space; extracellular region Molecular Function:insulin-like growth factor binding; protein binding Biological Process: negative regulation of cell proliferation; response to retinoic acid; response to cortisol stimulus; response to heat; regulation of steroid biosynthetic process; regulation of cell growth; cell adhesion; inner ear development; embryo implantation; cellular response to hormone stimulus Disease: Retinal Arterial Macroaneurysm With Supravalvular Pulmonic Stenosis |
| NCBI Summary: | This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q16270 |
| NCBI GenInfo Identifier: | 23396609 |
| NCBI Gene ID: | 3490 |
| NCBI Accession: | Q16270.1 |
| UniProt Related Accession: | Q16270 |
| Molecular Weight: | |
| NCBI Full Name: | Insulin-like growth factor-binding protein 7 |
| NCBI Synonym Full Names: | insulin like growth factor binding protein 7 |
| NCBI Official Symbol: | IGFBP7�� |
| NCBI Official Synonym Symbols: | AGM; PSF; TAF; FSTL2; IBP-7; MAC25; IGFBP-7; RAMSVPS; IGFBP-7v; IGFBPRP1�� |
| NCBI Protein Information: | insulin-like growth factor-binding protein 7 |
| UniProt Protein Name: | Insulin-like growth factor-binding protein 7 |
| UniProt Synonym Protein Names: | IGFBP-rP1; MAC25 protein; PGI2-stimulating factor; Prostacyclin-stimulating factor; Tumor-derived adhesion factor; TAF |
| Protein Family: | Insulin-like growth factor-binding protein |
| UniProt Gene Name: | IGFBP7�� |
| UniProt Entry Name: | IBP7_HUMAN |
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