Growth Factors & Cytokines Recombinant Proteins

Human IGFBP6 (28-240) Recombinant Protein (RPPB0437)

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RPPB0437

Description

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Product Name:Human IGFBP6 (28-240) Recombinant Protein
Product Code:RPPB0437
Size:10µg
Species:Human
Target:IGFBP6 (28-240)
Synonyms:Insulin-like growth factor-binding protein 6, IBP-6, IGF-binding protein 6, IGFBP-6, IGFBP6, IBP6.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The IGFBP6 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSRCPGCGQ GVQAGCPGGC VEEEDGGSPA EGCAEAEGCL RREGQECGVY TPNCAPGLQC HPPKDDEAPL RALLLGRGRC LPARAPAVAE ENPKESKPQA GTARPQDVNR RDQQRNPGTS TTPSQPNSAG VQDTEMGPCR RHLDSVLQQL QTEVYRGAQT LYVPNCDHRG FYRKRQCRSS QGQRRGPCWC VDRMGKSLPG SPDGNGSSSC PTGSSG

IGFBP6 plays a role in lipoprotein assembly and dietary cholesterol absorption. in addition to its acyltransferase activity, it may act as a ligase. may provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.

IGFBP6 Human Recombinant produced in E. coli is a single polypeptide chain containing 236 amino acids (28-240) and having a molecular mass of 25.0kDa (Molecular size on SDS-PAGE will appear higher).IGFBP6 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:IGFBP6: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
UniProt Protein Details:

Protein type:Cell cycle regulation; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: Golgi apparatus; extracellular space; extracellular region

Molecular Function:insulin-like growth factor I binding; insulin-like growth factor II binding

Biological Process: negative regulation of cell proliferation; regulation of insulin-like growth factor receptor signaling pathway; cellular protein metabolic process; regulation of cell growth; signal transduction

UniProt Code:P24592
NCBI GenInfo Identifier:124068
NCBI Gene ID:3489
NCBI Accession:P24592.1
UniProt Secondary Accession:P24592,Q14492,
UniProt Related Accession:P24592
Molecular Weight:25,322 Da
NCBI Full Name:Insulin-like growth factor-binding protein 6
NCBI Synonym Full Names:insulin-like growth factor binding protein 6
NCBI Official Symbol:IGFBP6��
NCBI Official Synonym Symbols:IBP6��
NCBI Protein Information:insulin-like growth factor-binding protein 6; IBP-6; IGFBP-6; IGF binding protein 6; IGF-binding protein 6
UniProt Protein Name:Insulin-like growth factor-binding protein 6
Protein Family:Insulin-like growth factor-binding protein
UniProt Gene Name:IGFBP6��
UniProt Entry Name:IBP6_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P24592
Research Area:
Growth Factors & Cytokines
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