Growth Factors & Cytokines Recombinant Proteins

Human IGFBP 1 Recombinant Protein (RPPB0430)

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RPPB0430

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human IGFBP 1 Recombinant Protein
Product Code:RPPB0430
Size:25µg
Species:Human
Target:IGFBP 1
Synonyms:IBP-1, IGF-Binding Protein 1, AFBP, PP12, IGF-BP25, hIGFBP-1, IGFBP-1.
Source:Mouse myeloma cell line, NS0
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:IGFBP-1 protein was lyophilized from a 0.2�m filtered concentrated solution in PBS.
Solubility:It is recommended to reconstitute the lyophilized IBP-1 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized IGFBP1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IGF-BP1 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:APWQCAPCSA EKLALCPPVS ASCSEVTRSA GCGCCPMCAL PLGAACGVAT ARCARGLSCR ALPGEQQPLH ALTRGQGACV QESDASAPHA AEAGSPESPE STEITEEELL DNFHLMAPSE EDHSILWDAI STYDGSKALH VTNIKKWKEP CRIELYRVVE SLAKAQETSG EEISKFYLPN CNKNGFYHSR QCETSMDGEA GLCWCVYPWN GKRIPGSPEI RGDPNCQIYF NVQN
Biological Activity:The ED50, as determined by the inhibition of rHuIGF-I-induced proliferation of human MCF-7 cells, is less than 4�g/ml.

IGFBP1 is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

IGFBP-1 Human Recombinant (26-259 a.a.) produced in NS0 is a single, glycosylated, polypeptide chain containing 234 amino acids and having a molecular mass of 25kDa. The IGFBP1 is purified by proprietary chromatographic techniques.

UniProt Protein Function:IGFBP1: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7p12.3

Cellular Component: extracellular region; extracellular space

Molecular Function:insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding

Biological Process: cellular protein metabolic process; insulin receptor signaling pathway; positive regulation of cell growth; regulation of insulin-like growth factor receptor signaling pathway; signal transduction; tissue regeneration; unfolded protein response

NCBI Summary:This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
UniProt Code:P08833
NCBI GenInfo Identifier:124055
NCBI Gene ID:3484
NCBI Accession:P08833.1
UniProt Secondary Accession:P08833,Q8IYP5, A4D2F4, D3DVL9,
UniProt Related Accession:P08833
Molecular Weight:27,904 Da
NCBI Full Name:Insulin-like growth factor-binding protein 1
NCBI Synonym Full Names:insulin like growth factor binding protein 1
NCBI Official Symbol:IGFBP1��
NCBI Official Synonym Symbols:AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1��
NCBI Protein Information:insulin-like growth factor-binding protein 1
UniProt Protein Name:Insulin-like growth factor-binding protein 1
UniProt Synonym Protein Names:Placental protein 12; PP12
Protein Family:Insulin-like growth factor-binding protein
UniProt Gene Name:IGFBP1��
UniProt Entry Name:IBP1_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P08833
Research Area:
Growth Factors & Cytokines
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