Human IGF1R/CD221/IGF-I R Recombinant Protein (His tag)
(No reviews yet)
Write a Review
- SKU:
- RPES5553
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
| Product Name: | Human IGF1R/CD221/IGF-I R Recombinant Protein (His tag) |
| Product Code: | RPES5553 |
| Size: | 20µg |
| Species: | Human |
| Expression Host: | E.coli |
| Synonyms: | CD221 antigen, CD221, IGF1R, IGF-1R, IGF-I R, IGF-I receptor, IGFIR, IGF-IR, IGFR, insulin-like growth factor 1 receptor, JTK13 |
| Mol Mass: | 32.45 kDa |
| AP Mol Mass: | 38 kDa |
| Tag: | N-His |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin Level: | Please contact us for more information. |
| Bio Activity: | Testing in progress |
| Sequence: | Asp 741-Asn 1036 |
| Accession: | P08069 |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation: | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution: | Please refer to the printed manual for detailed information. |
| Background: | The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide-linked heterotetrameric transmembrane protein consisting of two α and two β subunits, and among which, the α subunit is extracellular while the β subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The IGF-I receptor is highly expressed in all cell types and tissues. Essentially all of the biological activities of IGF-I and II have been shown to be mediated via IGF-I R. IGF1R is an important signaling molecule in cancer cells and plays an essential role in the establishment and maintenance of the transformed phenotype. Inhibition of IGF1R signaling thus appears to be a promising strategy to interfere with the growth and survival of cancer cells, is now an attractive anti-cancer treatment target. |
Related Products
Human IGF1R/CD221 Recombinant Protein (RPES1184)
system_update_altDatasheetHuman IGF1R/CD221 Recombinant Protein The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes inclu
Human IGF1R Recombinant Protein (His tag)
OverviewProduct Name:Human IGF1R Recombinant Protein (His tag)Product Code:RPES5987Size:20µgSpecies:HumanExpres
Recombinant Human IGF-I R/IGF1R (C-6His)
OverviewProduct Name:Recombinant Human IGF-I R/IGF1R (C-6His)Product Code:RPES6362Size:10µgSpecies:HumanExpress
chiken IGF1/IGF‑I/IGF-1 Recombinant Protein (His tag)
OverviewProduct Name:chiken IGF1/IGF‑I/IGF-1 Recombinant Protein (His tag)Product Code:RPES5817Size:20µgSpecies:Chicken
mouse IGF1/IGF‑I/IGF-1 Recombinant Protein (His tag)
OverviewProduct Name:mouse IGF1/IGF‑I/IGF-1 Recombinant Protein (His tag)Product Code:RPES5799Size:20µgSpecies:mouse