Cytokines Recombinant Proteins

Human IFNA14 Recombinant Protein (RPPB0390)

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SKU:
RPPB0390
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P01570
Research Area:
Cytokines

Description

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Product Name:Human IFNA14 Recombinant Protein
Product Code:RPPB0390
Size:20µg
Species:Human
Target:IFNA14
Synonyms:Interferon alpha-14, IFN-alpha-14, Interferon alpha-H, LeIF H, Interferon lambda-2-H, IFNA14, LEIF2H, IFN-alphaH.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:IFNA14 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 50% glycerol, 0.2M NaCl and 2mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMCNLSQ THSLNNRRTL MLMAQMRRIS PFSCLKDRHD FEFPQEEFDG NQFQKAQAIS VLHEMMQQTF NLFSTKNSSA AWDETLLEKF YIELFQQMND LEACVIQEVG VEETPLMNED SILAVKKYFQ RITLYLMEKK YSPCAWEVVR AEIMRSLSFS TNLQKRLRRK D

Interferon alpha-14 (IFNA14) is a member of the alpha/beta interferon family. IFNA14 is produced by macrophages (IFN-alpha have antiviral activities). The interferon stimulates the production of 2 enzymes: a protein kinase and an oligoadenylate synthetase.

IFNA14 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 191 amino acids (24-189 a.a.) and having a molecular mass of 22.4kDa.IFNA14 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:IFNA14: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Belongs to the alpha/beta interferon family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9p22

Cellular Component: extracellular space; extracellular region

Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor binding; interferon-alpha/beta receptor binding; cytokine activity

Biological Process: B cell proliferation; adaptive immune response; cytokine and chemokine mediated signaling pathway; regulation of MHC class I biosynthetic process; humoral immune response; T cell activation during immune response; response to exogenous dsRNA; B cell differentiation; natural killer cell activation during immune response; innate immune response; blood coagulation; defense response to virus; positive regulation of peptidyl-serine phosphorylation of STAT protein

UniProt Code:P01570
NCBI GenInfo Identifier:170763491
NCBI Gene ID:3448
NCBI Accession:NP_002163.2
UniProt Secondary Accession:P01570,P01566, P05014, P01567,
UniProt Related Accession:P01570
Molecular Weight:22,063 Da
NCBI Full Name:interferon alpha-14
NCBI Synonym Full Names:interferon, alpha 14
NCBI Official Symbol:IFNA14��
NCBI Official Synonym Symbols:LEIF2H; IFN-alphaH��
NCBI Protein Information:interferon alpha-14; IFN-alpha-14; interferon alpha-H; interferon lambda-2-H; leIF H
UniProt Protein Name:Interferon alpha-14
UniProt Synonym Protein Names:Interferon alpha-H; LeIF H; Interferon lambda-2-H
UniProt Gene Name:IFNA14��
UniProt Entry Name:IFN14_HUMAN
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