Growth Factors & Cytokines Recombinant Proteins
Human IFN-L1/IL-29 Recombinant Protein (RPES1908)
- SKU:
- RPES1908
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Growth Factors & Cytokines
Description
Human IFN-L1/IL-29 Recombinant Protein
Interleukin-29 (IL-29) is a secreted protein which belongs to the IL-28/IL-29 family. IL-29 is a cytokine with immunomodulatory activity. IL-29 is highly similar in amino acid sequence to the IL-28. IL-28 and IL-29 are induced by viral infection and showed antiviral activity. IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10R beta) and an orphan class II receptor chain, designated IL-28R alpha. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses. IL-29 may play a role in antiviral immunity. IL-29 up-regulates MHC class I antigen expression. It is a Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.
| Product Name: | Human IFN-L1/IL-29 Recombinant Protein (RPES1908) |
| Product Code: | RPES1908 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Interferon lambda-1, IFN-lambda-1, Cytokine Zcyto21, Interleukin-29, IL-29, IFNL1, IL29, ZCYTO21 |
| Accession: | Q8IU54 |
| Sequence: | Gly20-Thr200 |
| Fusion tag: | C-His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human IFN-?1 is produced by our Mammalian expression system and the target gene encoding Gly20-Thr200 is expressed with a 10His tag at the C-terminus. |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Mol Mass: | 21.4 kDa |
| AP Mol Mass: | 28-35 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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