Enzymes Recombinant Proteins
Human IDI1 Recombinant Protein (RPPB1842)
- SKU:
- RPPB1842
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q13907
- Research Area:
- Enzymes
Description
| Product Name: | Human IDI1 Recombinant Protein |
| Product Code: | RPPB1842 |
| Size: | 10µg |
| Species: | Human |
| Target: | IDI1 |
| Synonyms: | Isopentenyl-diphosphate Delta-isomerase 1, Isopentenyl pyrophosphate isomerase 1, IPP isomerase 1, IPPI1, IDI1, IPP1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The IDI1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 0.1M NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MMPEINTNHL DKQQVQLLAE MCILIDENDN KIGAETKKNC HLNENIEKGL LHRAFSVFLF NTENKLLLQQ RSDAKITFPG CFTNTCCSHP LSNPAELEES DALGVRRAAQ RRLKAELGIP LEEVPPEEIN YLTRIHYKAQ SDGIWGEHEI DYILLVRKNV TLNPDPNEIK SYCYVSKEEL KELLKKAASG EIKITPWFKI IAATFLFKWW DNLNHLNQFV DHEKIYRM |
Isopentenyl-diphosphate isomerase 1 (IDI1) belongs to the IPP isomerase type I family and is involved in cholesterol biosynthesis. IDI1 is a peroxisomally-localized enzyme which catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which is the substrate for the sequential reaction that results in the synthesis of farnesyl diphosphate and, eventually, cholesterol. Peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy show a reduction in IPP isomerase activity.
IDI1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 248 amino acids (1-228) and having a molecular mass of 28.6kDa.IDI1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IDI1: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Belongs to the IPP isomerase type 1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Isomerase; EC 5.3.3.2; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis Chromosomal Location of Human Ortholog: 10p15.3 Cellular Component: mitochondrion; peroxisome; cytosol Molecular Function:hydrolase activity; metal ion binding; manganese ion binding; magnesium ion binding; isopentenyl-diphosphate delta-isomerase activity Biological Process: isoprenoid biosynthetic process; cholesterol biosynthetic process; dimethylallyl diphosphate biosynthetic process |
| NCBI Summary: | IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13907 |
| NCBI GenInfo Identifier: | 40018633 |
| NCBI Gene ID: | 3422 |
| NCBI Accession: | NP_004499.2 |
| UniProt Secondary Accession: | Q13907,Q32Q13, Q53GQ6, Q86U81, Q8WUX8, Q96IZ4, Q9BQ74 B4E155, |
| UniProt Related Accession: | Q13907 |
| Molecular Weight: | |
| NCBI Full Name: | isopentenyl-diphosphate Delta-isomerase 1 |
| NCBI Synonym Full Names: | isopentenyl-diphosphate delta isomerase 1 |
| NCBI Official Symbol: | IDI1�� |
| NCBI Official Synonym Symbols: | IPP1; IPPI1�� |
| NCBI Protein Information: | isopentenyl-diphosphate Delta-isomerase 1; IPP isomerase 1; isopentenyl pyrophosphate isomerase 1; isopentenyl diphosphate dimethylallyl diphosphate isomerase 1 |
| UniProt Protein Name: | Isopentenyl-diphosphate Delta-isomerase 1 |
| UniProt Synonym Protein Names: | Isopentenyl pyrophosphate isomerase 1 |
| Protein Family: | Isopentenyl-diphosphate Delta-isomerase |
| UniProt Gene Name: | IDI1�� |
| UniProt Entry Name: | IDI1_HUMAN |
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