Immunology Recombinant Proteins
Human ICOS Ligand/ICOSL Recombinant Protein (RPES2030)
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- SKU:
- RPES2030
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Immunology
Description
system_update_altDatasheet
Human ICOS Ligand/ICOSL Recombinant Protein
Inducible Co-Stimulator Ligand (ICOSLG) belongs to the immunoglobulin superfamily. ICOSLG contains Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. ICOSLG acts as a costimulatory signal for T-cell proliferation and cytokine secretion, it also induces B-cell proliferation and differentiation into plasma cells. It could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. ICOSLG is widely expressed lymph nodes, leukocytes and spleen, detected on activated monocytes and dendritic cells.
| Product Name: | Human ICOS Ligand/ICOSL Recombinant Protein (RPES2030) |
| Product Code: | RPES2030 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | ICOS Ligand, B7 Homolog 2, B7-H2, B7-Like Protein Gl50, B7-Related Protein 1, B7RP-1, CD275, ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653 |
| Accession: | O75144 |
| Sequence: | Asp19-Ser258 |
| Fusion tag: | C-His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human ICOSL is produced by our Mammalian expression system and the target gene encoding Asp19-Ser258 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Mol Mass: | 27.72 kDa |
| AP Mol Mass: | 54 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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