Human ICAM2 Recombinant Protein (RPPB3728)
- SKU:
- RPPB3728
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P13598
Description
| Product Name: | Human ICAM2 Recombinant Protein |
| Product Code: | RPPB3728 |
| Size: | 10µg |
| Species: | Human |
| Target: | ICAM2 |
| Synonyms: | Intercellular Adhesion Molecule 2, ICAM2, ICAM-2, CD102, CD102 Antigen. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The ICAM2 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSSDEKVFE VHVRPKKLAV EPKGSLEVNC STTCNQPEVG GLETSLDKIL LDEQAQWKHY LVSNISHDTV LQCHFTCSGK QESMNSNVSV YQPPRQVILT LQPTLVAVGK SFTIECRVPT VEPLDSLTLF LFRGNETLHY ETFGKAAPAP QEATATFNST ADREDGHRNF SCLAVLDLMS RGGNIFHKHS APKMLEIYEP VSDSQ |
Intercellular Adhesion Molecule-2 (ICAM2) belongs to the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, containing 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. The ICAM2 protein has a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. ICAM2 mediates adhesive interactions vital for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and additional cellular interactions essential for immune response and surveillance.
ICAM2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 225 amino acids (22-223) and having a molecular mass of 24.8 kDa.ICAM2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ICAM2: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen- specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Belongs to the immunoglobulin superfamily. ICAM family. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral Chromosomal Location of Human Ortholog: 17q23.3 Cellular Component: membrane; integral to plasma membrane; plasma membrane; uropod Molecular Function:integrin binding Biological Process: extracellular matrix organization and biogenesis; cell-cell adhesion; regulation of immune response; cell adhesion |
| NCBI Summary: | The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P13598 |
| NCBI GenInfo Identifier: | 115502404 |
| NCBI Gene ID: | 3384 |
| NCBI Accession: | P13598.2 |
| UniProt Secondary Accession: | P13598,Q14600, |
| UniProt Related Accession: | P13598 |
| Molecular Weight: | 30,654 Da |
| NCBI Full Name: | Intercellular adhesion molecule 2 |
| NCBI Synonym Full Names: | intercellular adhesion molecule 2 |
| NCBI Official Symbol: | ICAM2�� |
| NCBI Official Synonym Symbols: | CD102�� |
| NCBI Protein Information: | intercellular adhesion molecule 2; ICAM-2 |
| UniProt Protein Name: | Intercellular adhesion molecule 2 |
| UniProt Synonym Protein Names: | CD_antigen: CD102 |
| Protein Family: | Intercellular adhesion molecule |
| UniProt Gene Name: | ICAM2�� |
| UniProt Entry Name: | ICAM2_HUMAN |
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