Chemokines Recombinant Proteins

Human I 309 Recombinant Protein (RPPB1161)

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RPPB1161

Description

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Product Name:Human I 309 Recombinant Protein
Product Code:RPPB1161
Size:10µg
Species:Human
Target:I 309
Synonyms:Small inducible cytokine A1, CCL1, T lymphocyte-secreted protein I-309, chemokine (C-C motif) ligand 1, P500, SISe, TCA3, I-309, SCYA1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The I-309 solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH 7.5), 2mM DTT, 10% glycerol and 50mM NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MKSMQVPFSR CCFSFAEQEI PLRAILCYRN TSSICSNEGL IFKLKRGKEA CALDTVGWVQ RHRKMLRHCP SKRK

Chemokine (C-C motif) ligand 1 (CCL1) is a small glycoprotein secreted by activated T cells that belongs to a family inflammatory cytokines known as chemokines. CCL1 attracts monocytes, NK cells, and immature B cells and dendritic cells by interacting with a cell surface chemokine receptor called CCR8. This chemokine resides in a large cluster of CC chemokines on human chromosome 17.

I-309 Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 94 amino acids (24-96 a.a.) and having a molecular mass of 10.8kDa. The I-309 is purified by proprietary chromatographic techniques.

UniProt Protein Function:CCL1: Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8. Belongs to the intercrine beta (chemokine CC) family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide; Chemokine; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular space

Molecular Function:chemokine activity

Biological Process: cellular calcium ion homeostasis; viral reproduction; immune response; chemotaxis; signal transduction

NCBI Summary:This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine (C-C motif) receptor 8. [provided by RefSeq, Sep 2014]
UniProt Code:P22362
NCBI GenInfo Identifier:123950
NCBI Gene ID:6346
NCBI Accession:P22362.1
UniProt Secondary Accession:P22362,Q2M309, B2R5G9,
UniProt Related Accession:P22362
Molecular Weight:10,992 Da
NCBI Full Name:C-C motif chemokine 1
NCBI Synonym Full Names:chemokine (C-C motif) ligand 1
NCBI Official Symbol:CCL1��
NCBI Official Synonym Symbols:P500; SISe; TCA3; I-309; SCYA1��
NCBI Protein Information:C-C motif chemokine 1; inflammatory cytokine I-309; T lymphocyte-secreted protein I-309; small inducible cytokine A1 (I-309, homologous to mouse Tca-3)
UniProt Protein Name:C-C motif chemokine 1
UniProt Synonym Protein Names:Small-inducible cytokine A1; T lymphocyte-secreted protein I-309
Protein Family:Cyclin
UniProt Gene Name:CCL1��
UniProt Entry Name:CCL1_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P22362
Research Area:
Chemokines
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