Growth Factors & Cytokines Recombinant Proteins
Human HVEM/TNFRSF14 Recombinant Protein (RPES4050)
- SKU:
- RPES4050
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Growth Factors & Cytokines
Description
Human HVEM/TNFRSF14 Recombinant Protein
Herpesvirus entry mediator (HVEM) is a type I membrane protein in the TNF receptor superfamily; and it can both promote and inhibit T cell activity. HVEM is highly expressed on na?ve CD4+ T cells; CD8+ T memory cells; regulatory T cells; dendritic cells; monocytes; and neutrophils. It functions as a receptor for BTLA; CD160; LIGHT/TNFSF14; and Lymphotoxin-alpha. Ligation of HVEM by LIGHT triggers T cell; monocyte; and neutrophil activation and contributes to Th1 inflammation and cardiac allograft rejection. In contrast; HVEM binding to CD160 or BTLA suppresses T cell and dendritic cell activation and dampens intestinal inflammation. HVEM enhances the development of CD8+ T cell memory and Treg function. It is additionally expressed on intestinal epithelial cells; where its binding by intraepithelial lymphocyte (IEL) expressed CD160 promotes epitheilal integrity and host defense. The herpesvirus envelope glycoprotein gD; which binds HVEM to initiate membrane fusion; can antagonize both BTLA and LIGHT binding.
| Product Name: | Human HVEM/TNFRSF14 Recombinant Protein (RPES4050) |
| Product Code: | RPES4050 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Tumor Necrosis Factor Receptor Superfamily Member 14, Herpes Virus Entry Mediator A, Herpesvirus Entry Mediator A, HveA, Tumor Necrosis Factor Receptor-Like 2, TR2, CD270 |
| Accession: | Q92956 |
| Sequence: | Leu39-Val202 |
| Fusion tag: | C-Fc |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human HVEM is produced by our Mammalian expression system and the target gene encoding Leu39-Val202 is expressed with a Fc tag at the C-terminus. |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Mol Mass: | 44.5 kDa |
| AP Mol Mass: | 50-60 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS;pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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