Human HTT / Huntingtin ELISA Kit

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SKU:
HUFI01070
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
P42858
Sensitivity:
9.375pg/ml
Range:
15.625-1000pg/ml
ELISA Type:
Sandwich
Synonyms:
HTT, Huntingtin, Huntington disease protein, HD protein, HD, IT15
Reactivity:
Human
Research Area:
Cell Death

Description

Human HTT / Huntingtin ELISA Kit

Huntington's disease is a neurodegenerative disorder characterised by the loss of striatal neurons. Huntingtin is a disease gene linked to Huntington's disease. An expanded, unstable trinucleotide repeat in the huntingtin gene, which translates to a polyglutamine repeat in the protein product, is thought to be the cause. In normal controls, a wide range of trinucleotide repeats (9-35) has been identified, and repeat numbers greater than 40 have been described as pathological. Huntingtin is a widely expressed gene that is required for normal development. It exists in two polyadenylated forms, each of which has a different relative abundance in various foetal and adult tissues. Huntington's disease is caused by a genetic defect that does not necessarily prevent transcription, but instead confers a new property on the mRNA or changes the function of the protein.

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