Human HSPA13 Recombinant Protein (RPPB5250)

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SKU:
RPPB5250
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P48723

Description

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Product Name:Human HSPA13 Recombinant Protein
Product Code:RPPB5250
Size:20µg
Species:Human
Target:HSPA13
Synonyms:Heat shock protein 70kDa family member 13, STCH, Stress 70 protein chaperone microsome-associated 60kD, Microsomal stress-70 protein ATPase core.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The HSPA13 protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0), 100mM NaCl, 1mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSELEM QQYLPLPTPK VIGIDLGTTY CSVGVFFPGT GKVKVIPDEN GHISIPSMVS FTDNDVYVGY ESVELADSNP QNTIYDAKRF IGKIFTAEEL EAEIGRYPFK VLNKNGMVEF SVTSNETITV SPEYVGSRLL LKLKEMAEAY LGMPVANAVI SVPAEFDLKQ RNSTIEAANL AGLKILRVIN EPTAAAMAYG LHKADVFHVL VIDLGGGTLD VSLLNKQGGM FLTRAMSGNN KLGGQDFNQR LLQYLYKQIY QTYGFVPSRK EEIHRLRQAV EMVKLNLTLH QSAQLSVLLT VEEQDRKEPH SSDTELPKDK LSSADDHRVN SGFGRGLSDK KSGESQVLFE TEISRKLFDT LNEDLFQKIL VPIQQVLKEG HLEKTEIDEV VLVGGSTRIP RIRQVIQEFF GKDPNTSVDP DLAVVTGVAI QAGIDGGFWP LQVSALEIPN KHLQKTNFN

HSPA13 belongs to the heat shock protein 70 family and is related to microsomes. Members of this protein family take part in the processing of cytosolic and secretory proteins, in addition to the exclusion of denatured or incorrectly-folded proteins. HSPA13 is known to cooperate with PLIC-1 and PLIC-2, proteins which have a role in the signaling connection between the membrane receptors for thrombospondin and the cytoskeleton.

HSPA13 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 489 amino acids (23-471a.a.) and having a molecular mass of 54.3 kDa. HSPA13 is fused to a 40 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:HSPA13: Has peptide-independent ATPase activity. Belongs to the heat shock protein 70 family.
UniProt Protein Details:

Protein type:Heat shock protein

Chromosomal Location of Human Ortholog: 21q11

Cellular Component: intracellular membrane-bound organelle; endoplasmic reticulum

Molecular Function:ATP binding

NCBI Summary:The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with microsomes. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly-folded proteins. The encoded protein contains an ATPase domain and has been shown to associate with a ubiquitin-like protein. [provided by RefSeq, Jul 2008]
UniProt Code:P48723
NCBI GenInfo Identifier:1351125
NCBI Gene ID:6782
NCBI Accession:P48723.1
UniProt Secondary Accession:P48723,Q8NE40, B2R616,
UniProt Related Accession:P48723
Molecular Weight:51,927 Da
NCBI Full Name:Heat shock 70 kDa protein 13
NCBI Synonym Full Names:heat shock protein 70kDa family, member 13
NCBI Official Symbol:HSPA13��
NCBI Official Synonym Symbols:STCH��
NCBI Protein Information:heat shock 70 kDa protein 13; microsomal stress 70 protein ATPase core; microsomal stress-70 protein ATPase core; stress 70 protein chaperone, microsome-associated, 60kD; stress 70 protein chaperone, microsome-associated, 60kDa; stress-70 protein chaperone microsome-associated 60 kDa protein
UniProt Protein Name:Heat shock 70 kDa protein 13
UniProt Synonym Protein Names:Microsomal stress-70 protein ATPase core; Stress-70 protein chaperone microsome-associated 60 kDa protein
Protein Family:Heat shock 70 kDa protein
UniProt Gene Name:HSPA13��
UniProt Entry Name:HSP13_HUMAN
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