Enzymes Recombinant Proteins
Human HSD17B11 Recombinant Protein (RPPB1833)
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- SKU:
- RPPB1833
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q8NBQ5
- Research Area:
- Enzymes
Description
| Product Name: | Human HSD17B11 Recombinant Protein |
| Product Code: | RPPB1833 |
| Size: | 20µg |
| Species: | Human |
| Target: | HSD17B11 |
| Synonyms: | 17-beta-hydroxysteroid dehydrogenase 11, 17-beta-HSD 11, 17bHSD11, 17betaHSD11, 17-beta-hydroxysteroid dehydrogenase XI, 17-beta-HSD XI, 17betaHSDXI, Cutaneous T-cell lymphoma-associated antigen HD-CL-03, CTCL-associated antigen HD-CL-03, Dehydrogenase/reductase SDR family member 8, Retinal short-chain dehydrogenase/reductase 2, retSDR2, HSD17B11, DHRS8, PAN1B, SDR16C2, 17BHSD11. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The HSD17B11 solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 5mM DTT and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MESFVKLFIP KRRKSVTGEI VLITGAGHGI GRLTAYEFAK LKSKLVLWDI NKHGLEETAA KCKGLGAKVH TFVVDCSNRE DIYSSAKKVK AEIGDVSILV NNAGVVYTSD LFATQDPQIE KTFEVNVLAH FWTTKAFLPA MTKNNHGHIV TVASAAGHVS VPFLLAYCSS KFAAVGFHKT LTDELAALQI TGVKTTCLCP NFVNTGFIKN PSTSLGPTLE PEEVVNRLMH GILTEQKMIF IPSSIAFLTT LERILPERFL AVLKQKI |
Dehydrogenase/reductase SDR family member 8 (HSD17B11) is a member of the HSD17B family of proteins, which regulate the availability of steroids within various tissues throughout the body. HSD17B11 is widely expressed with the highest levels found in the retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart as well as in steroidogenic cells.
HSD17B11 Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 287 amino acids (20-285 a.a.) and having a molecular mass of 31.4kDa. The HSD17B11 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | HSD17B11: Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor- associated antigen in cutaneous T-cell lymphoma. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.Protein type: Secreted, signal peptide; Secreted; Oxidoreductase; EC 1.1.1.62Chromosomal Location of Human Ortholog: 4q22.1Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; lipid particleMolecular Function: estradiol 17-beta-dehydrogenase activity; steroid dehydrogenase activityBiological Process: androgen catabolic process; estrogen biosynthetic process |
| UniProt Protein Details: | |
| NCBI Summary: | Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009] |
| UniProt Code: | Q8NBQ5 |
| NCBI GenInfo Identifier: | 296439374 |
| NCBI Gene ID: | 51170 |
| NCBI Accession: | Q8NBQ5.3 |
| UniProt Secondary Accession: | Q8NBQ5,Q96HF6, Q9UKU4 |
| UniProt Related Accession: | Q8NBQ5 |
| Molecular Weight: | 32,936 Da |
| NCBI Full Name: | Estradiol 17-beta-dehydrogenase 11 |
| NCBI Synonym Full Names: | hydroxysteroid 17-beta dehydrogenase 11 |
| NCBI Official Symbol: | HSD17B11�� |
| NCBI Official Synonym Symbols: | DHRS8; PAN1B; RETSDR2; SDR16C2; 17BHSD11; 17-BETA-HSD11; 17-BETA-HSDXI�� |
| NCBI Protein Information: | estradiol 17-beta-dehydrogenase 11 |
| UniProt Protein Name: | Estradiol 17-beta-dehydrogenase 11 |
| UniProt Synonym Protein Names: | 17-beta-hydroxysteroid dehydrogenase 11; 17-beta-HSD 11; 17bHSD11; 17betaHSD11; 17-beta-hydroxysteroid dehydrogenase XI; 17-beta-HSD XI; 17betaHSDXI; Cutaneous T-cell lymphoma-associated antigen HD-CL-03; CTCL-associated antigen HD-CL-03; Dehydrogenase/reductase SDR family member 8; Retinal short-chain dehydrogenase/reductase 2; retSDR2; Short chain dehydrogenase/reductase family 16C member 2 |
| Protein Family: | Estradiol 17 beta-dehydrogenase |
| UniProt Gene Name: | HSD17B11�� |
| UniProt Entry Name: | DHB11_HUMAN |
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