Human HSBP 1 Recombinant Protein (RPPB5227)

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RPPB5227

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Product Name:Human HSBP 1 Recombinant Protein
Product Code:RPPB5227
Size:50µg
Species:Human
Target:HSBP 1
Synonyms:NPC-A-13, HSBP1, Heat shock factor-binding protein 1, Nasopharyngeal carcinoma-associated antigen 13, HSF1BP, DKFZp686D1664, DKFZp686O24200.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The HSBP1 protein (1mg/ml) solution contains 20mM Tris-HCl buffer pH-7.5, 50mM NaCl, 1mM EDTA and 20% Glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MAETDPKTVQ DLTSVVQTLL QQMQDKFQTM SDQIIGRIDD MSSRIDDLEK NIADLMTQAG VEELESENKI PATQKS

The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein-1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.

Recombinant Human HSBP1 produced in E.Coli is a single,non-glycosylated polypeptide chain containing 76 amino acids and having a molecular mass of 8.5 kDa.

UniProt Protein Function:HSBP1: Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process. Belongs to the HSBP1 family.Chromosomal Location of Human Ortholog: 16q23.3Cellular Component: nucleoplasm; cytoskeleton; nucleusMolecular Function: transcription corepressor activityBiological Process: muscle contraction; negative regulation of transcription from RNA polymerase II promoter
UniProt Protein Details:
NCBI Summary:The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]
UniProt Code:O75506
NCBI GenInfo Identifier:119615920
NCBI Gene ID:3281
NCBI Accession:EAW95514.1
UniProt Secondary Accession:O75506,Q53XA8, Q7Z5Z3
UniProt Related Accession:O75506
Molecular Weight:
NCBI Full Name:heat shock factor binding protein 1
NCBI Synonym Full Names:heat shock factor binding protein 1
NCBI Official Symbol:HSBP1��
NCBI Official Synonym Symbols:NPC-A-13��
NCBI Protein Information:heat shock factor-binding protein 1; nasopharyngeal carcinoma-associated antigen 13
UniProt Protein Name:Heat shock factor-binding protein 1
UniProt Synonym Protein Names:Nasopharyngeal carcinoma-associated antigen 13; NPC-A-13
Protein Family:Heat shock factor-binding protein
UniProt Gene Name:HSBP1��
UniProt Entry Name:HSBP1_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O75506
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