Human HPR Recombinant Protein (RPPB3717)

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SKU:
RPPB3717
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P00739

Description

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Product Name:Human HPR Recombinant Protein
Product Code:RPPB3717
Size:10µg
Species:Human
Target:HPR
Synonyms:Haptoglobin-Related Protein, A-259H10.2, Haptoglobin-RelatedLocus, HP.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:HPR protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.5), 20% glycerol 1mM DTT and 0.15M NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
Purity:Greaterthan 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSLYSGNDV TDISDDRFPK PPEIANGYVE HLFRYQCKNY YRLRTEGDGVYTLNDKKQWI NKAVGDKLPE CEAVCGKPKN PANPVQRILG GHLDAKGSFP WQAKMVSHHN LTTGATLINEQWLLTTAKNL FLNHSENATA KDIAPTLTLY VGKKQLVEIE KVVLHPNYHQ VDIGLIKLKQ KVLVNERVMPICLPSKNYAE VGRVGYVSGW GQSDNFKLTD HLKYVMLPVA DQYDCITHYE GSTCPKWKAP KSPVGVQPILNEHTFCVGMS KYQEDTCYGD AGSAFAVHDL EEDTWYAAGI LSFDKSCAVA EYGVYVKVTS IQHWVQKTIA EN

Haptoglobin-RelatedProtein also known as HPR, is a primate-specific plasma protein related withapolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL) particleswhich shown to be a part of the innate immune defense. HPR-bound hemoglobin mightcontribute to the biologic activity of the circulating apoL-I/Hprcontaining HDLparticles. HPR is a clinically significant forecaster of recurrence of breastcancer.

HPR Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 352 amino acids (20-348 a.a) andhaving a molecular mass of 39.3kDa.HPR is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:HPR: a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: extracellular region

Biological Process: positive regulation of defense response to virus by host; receptor-mediated endocytosis

NCBI Summary:This gene encodes a haptoglobin-related protein that binds hemoglobin as efficiently as haptoglobin. Unlike haptoglobin, plasma concentration of this protein is unaffected in patients with sickle cell anemia and extensive intravascular hemolysis, suggesting a difference in binding between haptoglobin-hemoglobin and haptoglobin-related protein-hemoglobin complexes to CD163, the hemoglobin scavenger receptor. This protein may also be a clinically important predictor of recurrence of breast cancer. [provided by RefSeq, Oct 2011]
UniProt Code:P00739
NCBI GenInfo Identifier:262527547
NCBI Gene ID:3250
NCBI Accession:P00739.2
UniProt Secondary Accession:P00739,Q7LE20, Q92658, Q92659, Q9ULB0,
UniProt Related Accession:P00739
Molecular Weight:43,078 Da
NCBI Full Name:Haptoglobin-related protein
NCBI Synonym Full Names:haptoglobin-related protein
NCBI Official Symbol:HPR��
NCBI Official Synonym Symbols:HP; A-259H10.2��
NCBI Protein Information:haptoglobin-related protein
UniProt Protein Name:Haptoglobin-related protein
Protein Family:HPr-like protein
UniProt Gene Name:HPR��
UniProt Entry Name:HPTR_HUMAN
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