Human HPCAL1 Recombinant Protein (RPPB3716)

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SKU:
RPPB3716
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P37235

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human HPCAL1 Recombinant Protein
Product Code:RPPB3716
Size:10µg
Species:Human
Target:HPCAL1
Synonyms:Hippocalcin-Like 1, HLP2, BDR1, Calcium-Binding protein BDR-1, Visinin-Like protein 3, VILIP-3
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The HPCAL1 protein solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH8.0) containing 1mM DTT 0.2M NaCl and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGKQNSKLRP EVLQDLRENT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK IYANFFPYGD ASKFAEHVFR TFDTNGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISRSE MLEIVQAIYK MVSSVMKMPE DESTPEKRTD KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV RLLQCDPSSA SQF

HPCAL1, participates in neuron-specific calcium-binding proteins family found in the retina and brain. HPCAL1 is extremely comparable to human hippocalcin protein and almost equal to the rat and mouse hippocalcin like-1 proteins. HPCAL1 takes part in the calcium-dependent regulation of rhodopsin phosphorylation and can have importance in neuronal signalling in the central nervous system.

HPCAL1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 213amino acids (1-193a.a.) and having a molecular wieght of 24.4kDa. The HPCAL1 is fused to 20a.a. His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:HPCAL1: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Belongs to the recoverin family.
UniProt Protein Details:

Protein type:Calcium-binding

Chromosomal Location of Human Ortholog: 2p25.1

Molecular Function:protein binding

NCBI Summary:The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. It is highly similar to human hippocalcin protein and nearly identical to the rat and mouse hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation and may be of relevance for neuronal signalling in the central nervous system. Several alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2012]
UniProt Code:P37235
NCBI GenInfo Identifier:20455519
NCBI Gene ID:3241
NCBI Accession:P37235.3
UniProt Secondary Accession:P37235,Q969S5,
UniProt Related Accession:P37235
Molecular Weight:22,313 Da
NCBI Full Name:Hippocalcin-like protein 1
NCBI Synonym Full Names:hippocalcin like 1
NCBI Official Symbol:HPCAL1��
NCBI Official Synonym Symbols:BDR1; HLP2; VILIP-3��
NCBI Protein Information:hippocalcin-like protein 1
UniProt Protein Name:Hippocalcin-like protein 1
UniProt Synonym Protein Names:Calcium-binding protein BDR-1; HLP2; Visinin-like protein 3; VILIP-3
Protein Family:Hippocalcin-like protein
UniProt Gene Name:HPCAL1��
UniProt Entry Name:HPCL1_HUMAN
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system_update_altDatasheetHuman HPCAL1 Recombinant Protein Hippocalcin-Like Protein 1 (HPCAL1) is a neuron-specific calcium-binding member of the recoverin family which found in the retina and br