Human HOXA9 Recombinant Protein (RPPB3713)
- SKU:
- RPPB3713
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P31269
Description
| Product Name: | Human HOXA9 Recombinant Protein |
| Product Code: | RPPB3713 |
| Size: | 20µg |
| Species: | Human |
| Target: | HOXA9 |
| Synonyms: | Homeobox A9, HOX1G, Homeobox Protein Hox-1G, Homeodomain Protein HOXA9, Homeobox Protein Hox-A9, Homeo Box A9, HOX1.7, ABD-B, HOX1, HOXA9. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The HOXA9 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greaterthan 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMATTGAL GNYYVDSFLL GADAADELSV GRYAPGTLGQ PPRQAATLAE HPDFSPCSFQ SKATVFGASW NPVHAAGANA VPAAVYHHHH HHPYVHPQAP VAAAAPDGRY MRSWLEPTPG ALSFAGLPSS RPYGIKPEPL SARRGDCPTL DTHTLSLTDY ACGSPPVDRE KQPSEGAFSE NNAENESGGD KPPIDPNNPA ANWLHARSTR KKRCPYTKHQ TLELEKEFLF NMYLTRDRRY EVARLLNLTE RQVKIWFQNR RMKMKKINKD RAKDE |
Homeobox A9 (HOXA9) is a member of the Abd-B homeobox family. The HOXA9 protein is a transcription factor with a key role in both haemopoiesis and leukaemia. High levels of HOXA9 expression in haemopoietic cells is a distinctive feature of acute myeloid leukaemia (AML), and may be sufficient to cause this disease. HOXA9 overexpression noticeably expands hematopoietic stem cells. The HOXA9 gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which regulates gene expression, morphogenesis, and differentiation. HOXA9 is a sequence-specific transcription factor which is part of a developmental regulatory system, which provides cells with specific positional identities on the anterior-posterior axis. HOXA9 is essential for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation.
HOXA9 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 295 amino acids (1-272) and having a molecular mass of 32.6 kDa.HOXA9 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | HOXA9: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. A chromosomal aberration involving HOXA9 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with NUP98. A chromosomal aberration involving HOXA9 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with MSI2. Belongs to the Abd-B homeobox family. |
| UniProt Protein Details: | Protein type:DNA-binding; Oncoprotein Chromosomal Location of Human Ortholog: 7p15.2 Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus Molecular Function:protein binding; enzyme binding; sequence-specific DNA binding Biological Process: embryonic forelimb morphogenesis; negative regulation of myeloid cell differentiation; transcription, DNA-dependent; multicellular organismal development; embryonic skeletal development; male gonad development; uterus development; endothelial cell activation; anterior/posterior pattern formation; regulation of transcription, DNA-dependent; mammary gland development; single fertilization; spermatogenesis; proximal/distal pattern formation |
| NCBI Summary: | In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011] |
| UniProt Code: | P31269 |
| NCBI GenInfo Identifier: | 6166219 |
| NCBI Gene ID: | 3205 |
| NCBI Accession: | P31269.4 |
| UniProt Related Accession: | P31269 |
| Molecular Weight: | |
| NCBI Full Name: | Homeobox protein Hox-A9 |
| NCBI Synonym Full Names: | homeobox A9 |
| NCBI Official Symbol: | HOXA9�� |
| NCBI Official Synonym Symbols: | HOX1; ABD-B; HOX1G; HOX1.7�� |
| NCBI Protein Information: | homeobox protein Hox-A9 |
| UniProt Protein Name: | Homeobox protein Hox-A9 |
| UniProt Synonym Protein Names: | Homeobox protein Hox-1G |
| UniProt Gene Name: | HOXA9�� |
| UniProt Entry Name: | HXA9_HUMAN |
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