Human HOMER2 Recombinant Protein (RPPB3710)

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RPPB3710

Description

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Product Name:Human HOMER2 Recombinant Protein
Product Code:RPPB3710
Size:10µg
Species:Human
Target:HOMER2
Synonyms:Homer homolog 2 (Drosophila), homer neuronal immediate early gene 2, homer homolog 3, HOMER-2 (2A/2B), Vesl-2, ACPD, Cupidin, CPD.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The HOMER2 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 1mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMMGEQP IFTTRAHVFQ IDPNTKKNWM PASKQAVTVS YFYDVTRNSY RIISVDGAKV IINSTITPNM TFTKTSQKFG QWADSRANTV FGLGFSSEQQ LTKFAEKFQE VKEAAKIAKD KTQEKIETSS NHSQASSVNG TDDEKASHAG PANTHLKSEN DKLKIALTQS AANVKKWEIE LQTLRESNAR LTTALQESAA SVEQWKRQFS ICRDENDRLR NKIDELEEQC SEINREKEKN TQLKRRIEEL EAELREKETE LKDLRKQSEI IPQLMSECEY VSEKLEAAER DNQNLEDKVR SLKTDIEESK YRQRHLKVEL KSFLEVLDGK IDDLHDFRRG LSKLGTDN

HOMER2 belongs to the homer family of dendritic proteins which are immediate early gene products who bind to group 1 metabotropic glutamate receptors (mGluRs), proteins associated to triggering intracellular calcium release. Additionally, HOMER2 conect mGluRs to the inositol triphosphate receptors (IP3R).

HOMER2 Human Recombinant produced in E. coli is a single polypeptide chain containing 368 amino acids (1-343) and having a molecular mass of 42.1kDa.HOMER2 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (PubMed:9808459). Required for normal hearing (PubMed:25816005).
NCBI Summary:This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14. [provided by RefSeq, Jun 2011]
UniProt Code:Q9NSB8
NCBI GenInfo Identifier:46249349
NCBI Gene ID:9455
NCBI Accession:NP_004830.2
UniProt Secondary Accession:Q9NSB8,O95269, O95349, Q9NSB6, Q9NSB7, Q9UNT7,
UniProt Related Accession:Q9NSB8
Molecular Weight:39,467 Da
NCBI Full Name:homer protein homolog 2 isoform 1
NCBI Synonym Full Names:homer scaffold protein 2
NCBI Official Symbol:HOMER2��
NCBI Official Synonym Symbols:CPD; ACPD; DFNA68; VESL-2; HOMER-2��
NCBI Protein Information:homer protein homolog 2
UniProt Protein Name:Homer protein homolog 2
UniProt Synonym Protein Names:Cupidin
Protein Family:Homer protein
UniProt Gene Name:HOMER2��
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NSB8
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