Enzymes Recombinant Proteins

Human HMOX2 Recombinant Protein (RPPB1817)

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SKU:
RPPB1817
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P30519
Research Area:
Enzymes

Description

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Product Name:Human HMOX2 Recombinant Protein
Product Code:RPPB1817
Size:25µg
Species:Human
Target:HMOX2
Synonyms:EC 1.14.99.3, HO2, Heme oxygenase 2, HO-2, HMOX2.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:HMOX2 solution containing 20mM Tris pH-8, 1mM DTT and 10% glycerol.
Stability:HMOX2 Human Recombinant although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:SAEVETSEG VDESEKKNSG ALEKENQMRM ADLSELLKEG TKEAHDRAEN TQFVKDFLKG NIKKELFKLA TTALYFTYSA LEEEMERNKD HPAFAPLYFP MELHRKEALT KDMEYFFGEN WEEQVQCPKA AQKYVERIHY IGQNEPELLV AHAYTRYMGD LSGGQVLKKV AQRALKLPST GEGTQFYLFE NVDNAQQFKQ LYRARMNALD LNMKTKERIV EEANKAFEYN MQIFNELDQA GSTLARETLE DGFPVHDGKG DMRK

HMOX2 cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently transferred to bilirubin by biliverdin reductase. Under physiological conditions, the activity of HMOX2 is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. HMOX2 participates in the production of carbon monoxide in the brain where it operates as a neurotransmitter. HMOX2 is an essential enzyme in heme catabolism and is involved in cellular response to oxidative stress.

HMOX2 Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 264 amino acids (1-264 a.a.) and having a molecular mass of 30.5 kDa. HMOX2 is purified by proprietary chromatographic techniques.

UniProt Protein Function:HMOX2: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. Belongs to the heme oxygenase family.
UniProt Protein Details:

Protein type:Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.14.99.3; Endoplasmic reticulum; Oxidoreductase

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: endoplasmic reticulum membrane; membrane; plasma membrane

Molecular Function:heme binding; heme oxygenase (decyclizing) activity; protein binding

Biological Process: cellular iron ion homeostasis; heme catabolic process; heme oxidation; iron ion homeostasis; response to hypoxia; response to oxidative stress

NCBI Summary:Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
UniProt Code:P30519
NCBI GenInfo Identifier:1170328
NCBI Gene ID:3163
NCBI Accession:P30519.2
UniProt Secondary Accession:P30519,O60605, A8MT35, D3DUD5, I3L430,
UniProt Related Accession:P30519
Molecular Weight:32,837 Da
NCBI Full Name:Heme oxygenase 2
NCBI Synonym Full Names:heme oxygenase 2
NCBI Official Symbol:HMOX2��
NCBI Official Synonym Symbols:HO-2��
NCBI Protein Information:heme oxygenase 2
UniProt Protein Name:Heme oxygenase 2
UniProt Gene Name:HMOX2��
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