Immunology Recombinant Proteins
Human HMGB1 Recombinant Protein (RPES2218)
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- SKU:
- RPES2218
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Immunology
Description
system_update_altDatasheet
Human HMGB1 Recombinant Protein
B1 is a member of the HMGB family, which includes three other proteins: HMGB1, HMGB2, and HMGB3. It includes two HMG box DNA-binding domains - box A and B, which are highly negatively charged at their C termini. HMGB1 is a nuclear protein that maintains nucleosomes and permits DNA bending, which is required for gene transcription. Finally, it is shown that HMGB1 can also function as a cytokine extracellularly and regulate monocyte, T cell, dendritic cell activities in inflammatory responses. Human HMGB1 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
| Product Name: | Human HMGB1 Recombinant Protein (RPES2218) |
| Product Code: | RPES2218 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | E.coli |
| Synonyms: | High Mobility Group Protein B1, High Mobility Group Protein 1, HMG-1, HMGB1, HMG1 |
| Accession: | P09429 |
| Sequence: | Gly2-Phe89 |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human HMGB1 is produced by our E.coli expression system and the target gene encoding Gly2-Phe89 is expressed. |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Mol Mass: | 10.5 kDa |
| AP Mol Mass: | 14 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 50mMHepes;500mMNaCl;0.5mMDTT; pH7.9 . |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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