Immunology Recombinant Proteins
Human HMGB1 Recombinant Protein (RPES0734)
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- SKU:
- RPES0734
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Immunology
Description
system_update_altDatasheet
Human HMGB1 Recombinant Protein
High mobility group protein B1 is a member of the HMGB family consisting of three members; HMGB1; HMGB2 and HMGB3.It Contains 2 HMG box DNA-binding domains entitled box A and box B and It is a highly negative-charged C terminus. As a nuclear protein; HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. Meanwhile; it is revealed that HMGB1 can also act as a cytokine extracellularlly and regulates monocyte; T cell; dendritic cell activities in inflammatory responses.
| Product Name: | Human HMGB1 Recombinant Protein (RPES0734) |
| Product Code: | RPES0734 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | E.coli |
| Synonyms: | High Mobility Group Protein B1, High Mobility Group Protein 1, HMG-1, HMGB1, HMG1 |
| Accession: | P09429 |
| Sequence: | Pro92-Val176 |
| Fusion tag: | N-MARI |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human High mobility group protein B1 is produced by our E.coli expression system and the target gene encoding Pro92-Val176 is expressed with a MARI tag at the N-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 10.0 kDa |
| AP Mol Mass: | 13 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 50mM HEPES-Na;p H 7.9;500mM NaCl;0.6mM DTT. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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