Human HINT2 Recombinant Protein (RPPB3684)
- SKU:
- RPPB3684
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9BX68
Description
| Product Name: | Human HINT2 Recombinant Protein |
| Product Code: | RPPB3684 |
| Size: | 10µg |
| Species: | Human |
| Target: | HINT2 |
| Synonyms: | Histidine triad nucleotide-binding protein 2 mitochondrial, HINT-2, HINT-3 HIT-17kDa, PKCI-1-related HIT protein, HINT2, histidine triad nucleotide binding protein 2, HIT-17. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | HINT2 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSVAATGVR GGQVRGAAGV TDGNEVAKAQ QATPGGAAPT IFSRILDKSL PADILYEDQQ CLVFRDVAPQ APVHFLVIPK KPIPRISQAE EEDQQLLGHL LLVAKQTAKA EGLGDGYRLV INDGKLGAQS VYHLHIHVLG GRQLQWPPG |
Histidine triad nucleotide-binding protein 2 (HINT2) belongs to the triad proteins, which are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides. Hydrolase is most likely involved in steroid biosynthesis, furthermore it might play a role in apoptosis. HINT2 shows high expression in liver and pancreas. Expression is significantly down-regulated in hepatocellular carcinoma (HCC) patients.
HINT2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 169 amino acids (18-163 a.a) and having a molecular mass of 17.9kDa.HINT2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | HINT2: Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity. Belongs to the HINT family.Protein type: Hydrolase; EC 3.-.-.-Chromosomal Location of Human Ortholog: 9p13.3Cellular Component: mitochondrion; nucleolusMolecular Function: hydrolase activity; nucleotide bindingBiological Process: apoptosis; steroid biosynthetic process |
| UniProt Protein Details: | |
| NCBI Summary: | Histidine triad proteins, such as HINT2, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9BX68 |
| NCBI GenInfo Identifier: | 14211923 |
| NCBI Gene ID: | 84681 |
| NCBI Accession: | NP_115982.1 |
| UniProt Secondary Accession: | Q9BX68,Q5TCW3 |
| UniProt Related Accession: | Q9BX68 |
| Molecular Weight: | 17,162 Da |
| NCBI Full Name: | histidine triad nucleotide-binding protein 2, mitochondrial |
| NCBI Synonym Full Names: | histidine triad nucleotide binding protein 2 |
| NCBI Official Symbol: | HINT2�� |
| NCBI Official Synonym Symbols: | HIT-17�� |
| NCBI Protein Information: | histidine triad nucleotide-binding protein 2, mitochondrial; HINT-2; HINT-3; HIT-17kDa; PKCI-1-related HIT protein; protein kinase C inhibitor-2 |
| UniProt Protein Name: | Histidine triad nucleotide-binding protein 2, mitochondrial |
| UniProt Synonym Protein Names: | HINT-3; HIT-17kDa; PKCI-1-related HIT protein |
| Protein Family: | Histidine triad nucleotide-binding protein |
| UniProt Gene Name: | HINT2�� |
| UniProt Entry Name: | HINT2_HUMAN |
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