Growth Factors & Cytokines Recombinant Proteins

Human HGF Recombinant Protein (RPES0645)

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SKU:
RPES0645
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Growth Factors & Cytokines

Description

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Human HGF Recombinant Protein

Hepatocyte growth factor/scatter factor (HGF/SF) is a paracrine cellular growth, motility and morphogenic factor. It belongs to the peptidase S1 family and Plasminogen subfamily, contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. HGF regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. HGF is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration.

Product Name:Human HGF Recombinant Protein (RPES0645)
Product Code:RPES0645
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Hepatocyte growth factor,HPTA,HGF,SF,Scatter factor,Hepatopoietin-A
Accession:P14210
Sequence:Gln32-Ser728
Fusion tag:C-6His
Activity:Measured by its ability to induce IL-11 secretion by Saos?2 human osteosarcoma cells.  The ED50 for this effect is 0.3-1.5 ng/ml.
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Hepatocyte Growth Factor is produced by our Mammalian expression system and the target gene encoding Gln32-Ser728 is expressed with a 6His tag at the C-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:26&53.7&80.7 kDa
AP Mol Mass:105 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 20mM Tris,150mM NaCl,pH8.0.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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