Immune Checkpoint Recombinant Proteins

Human Her2 Recombinant Protein (His Tag) (HDPT0114)

(No reviews yet) Write a Review
SKU:
HDPT0114
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Immune Checkpoint

Description

Human Her2 Recombinant Protein (His Tag)

Description:This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Product name:Human Her2 Recombinant Protein (His Tag)
Synonyms:ERBB2,CD340,HER-2/neu,HER2,MLN19,NEU,NGL,TKR1
Type:protein
Size:50 µg
Name:Her2
Origin:Human
Source:HEK293
Protein Type:Recombinant
Application:Contact Technical Support
Purity:> 95%
Purification:affinity purification
Format:Lyophilized
Conjugate:C-6×His tag
Storage:Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Usage:Research use only
Buffer:Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Reconstitution:Reconstitute with deionized water
Sequence:Her2(Thr23-Thr652)+6×His tag
Gene ID:2064
Uniprot:P04626
Molecular Weight:100-130 kDa
View AllClose

0 Reviews

View AllClose