Enzymes Recombinant Proteins
Human HDDC3 Recombinant Protein (RPPB1804)
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- SKU:
- RPPB1804
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q8N4P3
- Research Area:
- Enzymes
Description
| Product Name: | Human HDDC3 Recombinant Protein |
| Product Code: | RPPB1804 |
| Size: | 20µg |
| Species: | Human |
| Target: | HDDC3 |
| Synonyms: | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1, HD domain-containing protein 3, Metazoan SpoT homolog 1, MESH1, Penta-phosphate guanosine-3'-pyrophosphohydrolase, (ppGpp)ase, HDDC3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The HDDC3 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 40% glycerol, 0.15M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSEAAQLLE AADFAARKHR QQRRKDPEGT PYINHPIGVA RILTHEAGIT DIVVLQAALL HDTVEDTDTT LDEVELHFGA QVRRLVEEVT DDKTLPKLER KRLQVEQAPH SSPGAKLVKL ADKLYNLRDL NRCTPEVKIQ |
Guanosine-3',5'-bis(diphosphate)-pyrophosphohydrolase MESH1 (HDDC3) contains an active site for ppGpp hydrolysis and a conserved His-Asp-box motif for Mn(2+) binding. In accordance with its structure, HDDC3 effectively catalyzes the hydrolysis of guanosine 3',5'-diphosphate (ppGpp) both in vitro and in vivo. In addition, HDDC3 suppresses SpoT-deficient lethality and RelA-induced delayed cell growth in bacteria.
HDDC3 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 160 amino acids (1-140) and having a molecular mass of 17.9kDa.HDDC3 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | HDDC3: ppGpp hydrolyzing enzyme involved in starvation response. Belongs to the MESH1 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.1.7.2Chromosomal Location of Human Ortholog: 15q26.1Molecular Function: guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity; metal ion bindingBiological Process: metabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8N4P3 |
| NCBI GenInfo Identifier: | 38348360 |
| NCBI Gene ID: | 374659 |
| NCBI Accession: | NP_940929.1 |
| UniProt Secondary Accession: | Q8N4P3 |
| UniProt Related Accession: | Q8N4P3 |
| Molecular Weight: | |
| NCBI Full Name: | guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform 2 |
| NCBI Synonym Full Names: | HD domain containing 3 |
| NCBI Official Symbol: | HDDC3�� |
| NCBI Official Synonym Symbols: | MESH1; (ppGpp)ase�� |
| NCBI Protein Information: | guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 |
| UniProt Protein Name: | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 |
| UniProt Synonym Protein Names: | HD domain-containing protein 3; Metazoan SpoT homolog 1; MESH1; Penta-phosphate guanosine-3'-pyrophosphohydrolase; (ppGpp)ase |
| Protein Family: | |
| UniProt Gene Name: | HDDC3�� |
| UniProt Entry Name: | MESH1_HUMAN |
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