Chemokines Recombinant Proteins

Human HCC 1 Recombinant Protein (RPPB1159)

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SKU:
RPPB1159
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q16627
Research Area:
Chemokines

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human HCC 1 Recombinant Protein
Product Code:RPPB1159
Size:10µg
Species:Human
Target:HCC 1
Synonyms:Small inducible cytokine A14, CCL14, Chemokine CC-1/CC-3, HCC-1/HCC-3, HCC-1(1-74), NCC-2, chemokine (C-C motif) ligand 14, CC-1, CC-3, CKb1, MCIF, SY14, HCC-1, HCC-3, SCYL2, SCYA14.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The HCC-1 solution (0.5 mg/ml) contains Phosphate Buffered Saline pH7.4 containing 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MTKTESSSRG PYHPSECCFT YTTYKIPRQR IMDYYETNSQ CSKPGIVFIT KRGHSVCTNP SDKWVQDYIK DMKEN

Chemokine (C-C motif) ligand 14 (CCL14) is a small cytokine belonging to the CC chemokine family. It is also commonly known as HCC-1. It is produced as a protein precursor that is procesed to generate a mature active protein containing 74 amino acids that and is 46% identical in amino acid composition to CCL3 and CCL4. This chemokine is expressed in various tissues including spleen, bone marrow, liver, muscle, and gut. CCL13 activates monocytes, but does not induce their chemotaxis. Human CCL13 is located on chromosome 17 within a cluster of other chemokines belonging to the CC family.

HCC-1 Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 95 amino acids (20-93 a.a.) and having a molecular mass of 10.9kDa. The HCC-1 is purified by proprietary chromatographic techniques.

UniProt Protein Function:CCL14: Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induced intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and was inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5. Belongs to the intercrine beta (chemokine CC) family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular space

Molecular Function:chemokine activity

Biological Process: cellular calcium ion homeostasis; positive regulation of cell proliferation; immune response

NCBI Summary:This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Read-through transcripts are also expressed that include exons from the upstream cytokine gene, chemokine (C-C motif) ligand 15, and are represented as GeneID: 348249. [provided by RefSeq, Dec 2009]
UniProt Code:Q16627
NCBI GenInfo Identifier:14589959
NCBI Gene ID:6358
NCBI Accession:NP_116738.1
UniProt Secondary Accession:Q16627,Q13954, E1P649, E1P650,
UniProt Related Accession:Q16627
Molecular Weight:~9.5 kDa
NCBI Full Name:C-C motif chemokine 14 isoform 2
NCBI Synonym Full Names:chemokine (C-C motif) ligand 14
NCBI Official Symbol:CCL14��
NCBI Official Synonym Symbols:CC-1; CC-3; CKB1; MCIF; NCC2; SY14; HCC-1; HCC-3; NCC-2; SCYL2; SCYA14; HCC-1(1-74); HCC-1/HCC-3��
NCBI Protein Information:C-C motif chemokine 14
UniProt Protein Name:C-C motif chemokine 14
UniProt Synonym Protein Names:Chemokine CC-1/CC-3; HCC-1/HCC-3
Protein Family:C-C motif chemokine
UniProt Gene Name:CCL14��
UniProt Entry Name:CCL14_HUMAN
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system_update_altDatasheetHuman CCL14/HCC-3 Recombinant Protein Chemokine (C-C motif) Ligand 14 (CCL14) is a small cytokine belonging to the CC chemokine family. It is produced as a protein precu