Human HBQ1 Recombinant Protein (RPPB3664)
- SKU:
- RPPB3664
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P09105
Description
| Product Name: | Human HBQ1 Recombinant Protein |
| Product Code: | RPPB3664 |
| Size: | 20µg |
| Species: | Human |
| Target: | HBQ1 |
| Synonyms: | Hemoglobin Theta 1, Hemoglobin Theta-1 Chain, Hemoglobin Subunit Theta-1, Theta-1-globin. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The HBQ1 solution contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMALSAED RALVRALWKK LGSNVGVYTT EALERTFLAF PATKTYFSHL DLSPGSSQVR AHGQKVADAL SLAVERLDDL PHALSALSHL HACQLRVDPA SFQLLGHCLL VTLARHYPGD FSPALQASLD KFLSHVISAL VSEYR |
HBQ1 is a member of the Hemoglobin family. Hemoglobin is a 66.7 kDa protein attached to four iron-binding, methenelinked tetrapyrrole rings (heme). The globin part of Hemoglobin contains 2 alpha chains and 2 beta chains organized as couples creating a tetramer. Every one of the 4 globin chains covalently connects with a heme group. The bonds between�alpha�and�beta�chains are frailer than between parallel globin chains, thus creating a cleavage plane which is vital for oxygen binding and release. Relaxation of the alpha1-beta2 cleavage plane results in high affinity for oxygen.
HBQ1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 165 amino acids (1-142) and having a molecular mass of 17.9kDa.HBQ1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | HBQ1: Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-2 -pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue. [provided by RefSeq, Jul 2008]Chromosomal Location of Human Ortholog: 16p13.3Cellular Component: hemoglobin complexMolecular Function: iron ion binding; heme binding; oxygen binding; oxygen transporter activityBiological Process: oxygen transport |
| UniProt Protein Details: | |
| NCBI Summary: | Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-2 -pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P09105 |
| NCBI GenInfo Identifier: | 122330 |
| NCBI Gene ID: | 3049 |
| NCBI Accession: | P09105.2 |
| UniProt Secondary Accession: | P09105,Q13723, Q1W6G5 |
| UniProt Related Accession: | P09105 |
| Molecular Weight: | |
| NCBI Full Name: | Hemoglobin subunit theta-1 |
| NCBI Synonym Full Names: | hemoglobin, theta 1 |
| NCBI Official Symbol: | HBQ1�� |
| NCBI Official Synonym Symbols: | HBQ�� |
| NCBI Protein Information: | hemoglobin subunit theta-1; hemoglobin theta-1 chain; theta-1-globin |
| UniProt Protein Name: | Hemoglobin subunit theta-1 |
| UniProt Synonym Protein Names: | Hemoglobin theta-1 chain; Theta-1-globin |
| Protein Family: | Hemoglobin |
| UniProt Gene Name: | HBQ1�� |
| UniProt Entry Name: | HBAT_HUMAN |
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