Human HAUS1 Recombinant Protein (RPPB3659)

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SKU:
RPPB3659
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q96CS2

Description

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Product Name:Human HAUS1 Recombinant Protein
Product Code:RPPB3659
Size:10µg
Species:Human
Target:HAUS1
Synonyms:HAUS augmin-like complex subunit 1, Coiled-coil domain-containing protein 5, Enhancer of invasion-cluster, HEI-C, HAUS1, CCDC5, HEIC, HsT1461.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:HAUS1 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 50% glycerol, 0.2M NaCl and 2mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMEPQEE RETQVAAWLK KIFGDHPIPQ YEVNPRTTEI LHHLSERNRV RDRDVYLVIE DLKQKASEYE SEAKYLQDLL MESVNFSPAN LSSTGSRYLN ALVDSAVALE TKDTSLASFI PAVNDLTSDL FRTKSKSEEI KIELEKLEKN LTATLVLEKC LQEDVKKAEL HLSTERAKVD NRRQNMDFLK AKSEEFRFGI KAAEEQLSAR GMDASLSHQS LVALSEKLAR LKQQTIPLKK KLESYLDLMP NPSLAQVKIE EAKRELDSIE AELTRRVDMM EL

HAUS augmin-like complex subunit 1 (HAUS1) is 1 of 8 subunits of the 390kDa human augmin complex/ HAUS complex. The augmin complex is a microtubule-binding complex required in microtubule generation within the mitotic spindle and is imperative to mitotic spindle compilation. HAUS1 contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. HAUS1 is broadly expressed, especially in the pancreas, kidney, skeletal muscle, liver and heart. However it is weakly expressed in the lung, brain and placenta. HAUS1-depleted cells hold functional cell cycle checkpoints, but the depletion reduces the G2/M cell cycle compartment and stimulates apoptosis. The HAUS1 protein level remains constant through the cell cycle.

HAUS1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 302 amino acids (1-278 a.a) and having a molecular mass of 34.4kDa.HAUS1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
NCBI Summary:HAUS1 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]
UniProt Code:Q96CS2
NCBI GenInfo Identifier:19923971
NCBI Gene ID:115106
NCBI Accession:NP_612452.1
UniProt Secondary Accession:Q96CS2,Q8N837, B2RDM7,
UniProt Related Accession:Q96CS2
Molecular Weight:22,744 Da
NCBI Full Name:HAUS augmin-like complex subunit 1
NCBI Synonym Full Names:HAUS augmin like complex subunit 1
NCBI Official Symbol:HAUS1��
NCBI Official Synonym Symbols:HEIC; CCDC5; HEI-C; HsT1461��
NCBI Protein Information:HAUS augmin-like complex subunit 1
UniProt Protein Name:HAUS augmin-like complex subunit 1
UniProt Synonym Protein Names:Coiled-coil domain-containing protein 5; Enhancer of invasion-cluster; HEI-C
Protein Family:HAUS augmin-like complex
UniProt Gene Name:HAUS1��
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