Immunology Recombinant Proteins
Human Haptoglobin/Zonulin Recombinant Protein (RPES0239)
- SKU:
- RPES0239
Description
Human Haptoglobin/Zonulin Recombinant Protein
Haptoglobin(HP) is a secreted protein which is a member of the peptidase S1 family of serine proteases. As a result of hemolysis; hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures; and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin; also known as zonulin; plays a role in intestinal permeability; allowing intercellular tight junction disassembly; and controlling the equilibrium between tolerance and immunity to non-self antigens.
| Product Name: | Human Haptoglobin/Zonulin Recombinant Protein (RPES0239) |
| Product Code: | RPES0239 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Haptoglobin,Zonulin,HP |
| Accession: | P00738 |
| Sequence: | Val19-Gln160&Ile162-Asn406 |
| Fusion tag: | C-6His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Haptoglobin/Zonulin is produced by our Mammalian expression system and the target gene encoding Val19-Gln160(alpha chain)&Ile162-Asn406(beta chain) is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 15.9&28.3 |
| AP Mol Mass: | 120 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS; 1mM DTT; pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Additional Information
Product Type: |
Recombinant Protein |
Species: |
Human |
Research Area: |
Immunology |
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