Enzymes Recombinant Proteins

Human GZMK Recombinant Protein (RPPB1785)

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SKU:
RPPB1785
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P49863
Research Area:
Enzymes

Description

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Product Name:Human GZMK Recombinant Protein
Product Code:RPPB1785
Size:20µg
Species:Human
Target:GZMK
Synonyms:Granzyme K, Fragmentin-3, Granzyme-3, NK-tryptase-2, NK-Tryp-2, GZMK, TRYP2, Granzyme-K.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:GZMK protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSIIGGKEV SPHSRPFMAS IQYGGHHVCG GVLIDPQWVL TAAHCQYRFT KGQSPTVVLG AHSLSKNEAS KQTLEIKKFI PFSRVTSDPQ SNDIMLVKLQ TAAKLNKHVK MLHIRSKTSL RSGTKCKVTG WGATDPDSLR PSDTLREVTV TVLSRKLCNS QSYYNGDPFI TKDMVCAGDA KGQKDSCKGD SGGPLICKGV FHAIVSGGHE CGVATKPGIY TLLTKKYQTW IKSNLVPPHT N

GZMK is a part of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes and natural killer cells have the outstanding ability to bind, recognize and lyse specific target cells. They defend their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens.

GZMK Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 261 amino acids (27-264 a.a.) and having a molecular mass of 28.2kDa.GZMK is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

NCBI Summary:This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. [provided by RefSeq, Jul 2008]
UniProt Code:P49863
NCBI GenInfo Identifier:1708035
NCBI Gene ID:3003
NCBI Accession:P49863.1
UniProt Secondary Accession:P49863,B2R563,
UniProt Related Accession:P49863
Molecular Weight:
NCBI Full Name:Granzyme K
NCBI Synonym Full Names:granzyme K
NCBI Official Symbol:GZMK��
NCBI Official Synonym Symbols:TRYP2��
NCBI Protein Information:granzyme K
UniProt Protein Name:Granzyme K
UniProt Synonym Protein Names:Fragmentin-3; Granzyme-3; NK-tryptase-2; NK-Tryp-2
Protein Family:Granzyme
UniProt Gene Name:GZMK��
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