Enzymes Recombinant Proteins

Human GZMH Recombinant Protein (RPPB1787)

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SKU:
RPPB1787
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P20718
Research Area:
Enzymes

Description

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Product Name:Human GZMH Recombinant Protein
Product Code:RPPB1787
Size:10µg
Species:Human
Target:GZMH
Synonyms:Granzyme H (Cathepsin G-Like 2, Protein H-CCPX), CTSGL2, Cytotoxic T-Lymphocyte Proteinase, CCP-X, CSP-C, Cytotoxic T-Lymphocyte-Associated Serine Esterase 1, Cytotoxin Serine Protease-C, Cytotoxic Serine Protease C, Cathepsin G-Like 2, EC 3.4.21.79, EC 3.4.21, Granzyme H, EC 3.4.21, CGL-2, CTLA1, CGL2, GZMH.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:GZMH protein solution (0.25mg/ml) containing 20mM Tris-HCl (pH 8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MEIIGGHEAK PHSRPYMAFV QFLQEKSRKR CGGILVRKDF VLTAAHCQGS SINVTLGAHN IKEQERTQQF IPVKRPIPHP AYNPKNFSND IMLLQLERKA KWTTAVRPLR LPSSKAQVKP GQLCSVAGWG YVSMSTLATT LQEVLLTVQK DCQCERLFHG NYSRATEICV GDPKKTQTGF KGDSGGPLVC KDVAQGILSY GNKKGTPPGV YIKVSHFLPW IKRTMKRL

Granzyme H also known as GZMH belongs to the peptidase S1 family. GZMHis an essential part for HBV eradication. The HBx protein, which is requiredfor the replication of HBV, is cleaved at Met(79) by GZMH. Furthermore, GZMHinhibitor can abolish GZNH- as well as lymphokine-activated killercell-mediated HBx degradation and HBV clearance. A HBx-deficient HBV isresistant to GzmH- in addition to lymphokine-activated killer cell-mediatedviral clearance.

GZMH Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 248 amino acids (20-246 a.a) and having a molecular mass of 27.5kDa.GZMH is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:GZMF: Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Belongs to the peptidase S1 family. Granzyme subfamily.
UniProt Protein Details:

Protein type:Protease; EC 3.4.21.-

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: cytoplasm; intracellular membrane-bound organelle; membrane

Molecular Function:serine-type endopeptidase activity

Biological Process: immune response; protein processing

NCBI Summary:This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. [provided by RefSeq, Nov 2015]
UniProt Code:P20718
NCBI GenInfo Identifier:121590
NCBI Gene ID:2999
NCBI Accession:P20718.1
UniProt Secondary Accession:P20718,Q6XGZ0, Q6XGZ1, G3V2C5,
UniProt Related Accession:P20718
Molecular Weight:12,609 Da
NCBI Full Name:Granzyme H
NCBI Synonym Full Names:granzyme H
NCBI Official Symbol:GZMH��
NCBI Official Synonym Symbols:CCP-X; CGL-2; CSP-C; CTLA1; CTSGL2��
NCBI Protein Information:granzyme H
UniProt Protein Name:Granzyme H
UniProt Synonym Protein Names:CCP-X; Cathepsin G-like 2; CTSGL2; Cytotoxic T-lymphocyte proteinase; Cytotoxic serine protease C; CSP-C
Protein Family:Granzyme
UniProt Gene Name:GZMH��
UniProt Entry Name:GRAH_HUMAN
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