Description
| Product Name: | Human GULP1 Recombinant Protein |
| Product Code: | RPPB3649 |
| Size: | 20µg |
| Species: | Human |
| Target: | GULP1 |
| Synonyms: | GULP, Engulfment Adaptor PTB Domain Containing 1, PTBDomain Adapter Protein CED-6, Cell Death Protein 6 Homolog, CED6, GULP, PTB Domain Adaptor ProteinCED-6 Engulfment Adapter Protein,Protein GULP, CED-6. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterilefiltered colorless solution. |
| Formulation: | GULP1 protein solution (0.5mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.15M NaCl, 50% glycerol and 2mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMNRAFSR KKDKTWMHTP EALSKHFIPY NAKFLGSTEV EQPKGTEVVRDAVRKLKFAR HIKKSEGQKI PKVELQISIY GVKILEPKTK EVQHNCQLHR ISFCADDKTD KRIFTFICKDSESNKHLCYV FDSEKCAEEI TLTIGQAFDL AYRKFLESGG KDVETRKQIA GLQKRIQDLE TENMELKNKVQDLENQLRIT QVSAPPAGSM TPKSPSTDIF DMIPFSPISH QSSMPTRNGT QPPPVPSRST EIKRDLFGAEPFDPFNCGAA DFPPDIQSKL DEMQEGFKMG LTLEGTVFCL DPLDSRC |
PTB domain-containing engulfment adapter protein 1 (GULP1) is an evolutionarily conserved adaptor protein essential for efficient phagocytosis of apoptotic cells by phagocytes. Furthermore, GULP1 helps modulate cellular glycosphingolipid and cholesterol transport. In addition, GULP1 may have a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increased cytoplasmic levels of GULP1 are linked with increases in cellular levels of GTP-bound ARF6.
GULP1 Human Recombinant produced in E. coli is a single,non-glycosylated polypeptide chain containing 327 amino acids (1-304a.a) andhaving a molecular mass of 36.9kDa.GULP1 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GULP1: May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6. Belongs to the ced-6 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 2q32.3-q33 Cellular Component: cytoplasm Molecular Function:signal transducer activity Biological Process: apoptosis; phagocytosis, engulfment; lipid transport; signal transduction |
| NCBI Summary: | The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q9UBP9 |
| NCBI GenInfo Identifier: | 74720076 |
| NCBI Gene ID: | 51454 |
| NCBI Accession: | Q9UBP9.1 |
| UniProt Secondary Accession: | Q9UBP9,Q53PC1, Q53RF3, Q9BVL3, B2RB51, B4DQ40, B8ZZ72 D3DPH1, E9PB86, |
| UniProt Related Accession: | Q9UBP9 |
| Molecular Weight: | 304 |
| NCBI Full Name: | PTB domain-containing engulfment adapter protein 1 |
| NCBI Synonym Full Names: | GULP, engulfment adaptor PTB domain containing 1 |
| NCBI Official Symbol: | GULP1�� |
| NCBI Official Synonym Symbols: | CED6; GULP; CED-6�� |
| NCBI Protein Information: | PTB domain-containing engulfment adapter protein 1; cell death protein 6 homolog; PTB domain adapter protein CED-6; PTB domain adaptor protein CED-6 |
| UniProt Protein Name: | PTB domain-containing engulfment adapter protein 1 |
| UniProt Synonym Protein Names: | Cell death protein 6 homolog; PTB domain adapter protein CED-6; Protein GULP |
| Protein Family: | PTB domain-containing engulfment adapter protein |
| UniProt Gene Name: | GULP1�� |
| UniProt Entry Name: | GULP1_HUMAN |
