Human GSAP / PION ELISA Kit

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SKU:
HUFI01757
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
A4D1B5
Sensitivity:
0.938ng/ml
Range:
1.563-100ng/ml
ELISA Type:
Sandwich
Synonyms:
PION, GSAP, Protein pigeon homolog
Reactivity:
Human

Description

Human GSAP / PION ELISA

Pontocerebellar hypoplasia, type 3, and Alzheimer's disease are examples of conditions linked to GSAP/ PION (Gamma-Secretase Activating Protein). Alzheimer's disease is characterized by the accumulation of neurotoxic amyloid beta. Amyloid-beta is made by the enzyme gamma-secretase. PION, or GSAP, increases amyloid-beta production through a mechanism that involves its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein C-terminal fragment (APP-CTF).

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