Chemokines Recombinant Proteins

Human GRO g Recombinant Protein (RPPB1151)

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SKU:
RPPB1151
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P19876
Research Area:
Chemokines

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human GRO g Recombinant Protein
Product Code:RPPB1151
Size:10µg
Species:Human
Target:GRO g
Synonyms:Macrophage inflammatory protein 2-beta, MIP2-beta, CXCL3, Growth-regulated protein gamma, GRO-gamma, GRO-gamma(1-73), GRO3, GROg, MIP2B, SCYB3, MIP-2b, CINC-2b, MGSA gamma.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:The protein was lyophilized with no additives.
Solubility:It is recommended to reconstitute the lyophilized CXCL3 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized GRO-gamma although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL3 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 98.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Ser-Val-Val-Thr
Biological Activity:The Biological activity is calculated by its ability to chemoattract CXCR2 transfected 293 cells using 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

Chemokine (C-X-C motif) ligand 3 (CXCL3) is a small cytokine belonging to the CXC chemokine family that is also known as GRO3 oncogene (GRO3), GRO protein gamma (GROg) and macrophage inflammatory protein-2-beta (MIP2b). CXCL3 controls migration and adhesion of monocytes and mediates it effects on its target cell by interacting with a cell surface chemokine receptor called CXCR2. The gene for CXCL3 is located on chromosome 4 in a cluster of other CXC chemokines.

GRO-Gamma Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 73 amino acids and having a molecular mass of 7902 Dalton. The CXCL3 is purified by proprietary chromatographic techniques.

UniProt Protein Function:CXCL3: Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. Belongs to the intercrine alpha (chemokine CxC) family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function:chemokine activity; CXCR chemokine receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; neutrophil chemotaxis; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; immune response; inflammatory response; regulation of cell proliferation

NCBI Summary:This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]
UniProt Code:P19876
NCBI GenInfo Identifier:127086
NCBI Gene ID:2921
NCBI Accession:P19876.1
UniProt Secondary Accession:P19876,Q4W5H9,
UniProt Related Accession:P19876
Molecular Weight:11,342 Da
NCBI Full Name:C-X-C motif chemokine 3
NCBI Synonym Full Names:chemokine (C-X-C motif) ligand 3
NCBI Official Symbol:CXCL3��
NCBI Official Synonym Symbols:GRO3; GROg; MIP2B; SCYB3; MIP-2b; CINC-2b��
NCBI Protein Information:C-X-C motif chemokine 3; GRO-gamma; MIP2-beta; MGSA gamma; GRO3 oncogene; GRO-gamma(1-73); growth-regulated protein gamma; macrophage inflammatory protein 2-beta; melanoma growth stimulatory activity gamma
UniProt Protein Name:C-X-C motif chemokine 3
UniProt Synonym Protein Names:GRO-gamma(1-73); Growth-regulated protein gamma; GRO-gamma; Macrophage inflammatory protein 2-beta; MIP2-beta
UniProt Gene Name:CXCL3��
UniProt Entry Name:CXCL3_HUMAN
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