Chemokines Recombinant Proteins

Human GRO b Recombinant Protein (RPPB1147)

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SKU:
RPPB1147
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P19875
Research Area:
Chemokines

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human GRO b Recombinant Protein
Product Code:RPPB1147
Size:10µg
Species:Human
Target:GRO b
Synonyms:Macrophage inflammatory protein 2-alpha, MIP2-alpha, CXCL2, Growth- regulated protein beta, Gro-beta, chemokine (C-X-C motif) ligand 2, GRO2, GROb, MIP2, MIP2A, SCYB2, MGSA-b, MIP-2a, CINC-2a, MGSA beta.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The Human CXCL2 protein solution contains 20mM Tris HCl�(pH 8.0).
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MAPLATELRC QCLQTLQGIH LKNIQSVKVK SPGPHCAQTE VIATLKNGQK ACLNPASPMV KKIIEKMLKNGKSN

Chemokine (C-X-C motif) ligand 2 (CXCL2) is a small cytokine belonging to the CXC chemokine family that is also called macrophage inflammatory protein 2-alpha (MIP2-alpha), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2). CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. This chemokine is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines. CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2.

GRO-Beta Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 94 amino acids (35-107 a.a) and having a molecular mass of 10.1 kDa. The GRO-b is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity.
NCBI Summary:This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]
UniProt Code:P19875
NCBI GenInfo Identifier:127085
NCBI Gene ID:2920
NCBI Accession:P19875.1
UniProt Secondary Accession:P19875,Q6FGD6, Q9UPB8,
UniProt Related Accession:P19875
Molecular Weight:11,389 Da
NCBI Full Name:C-X-C motif chemokine 2
NCBI Synonym Full Names:C-X-C motif chemokine ligand 2
NCBI Official Symbol:CXCL2��
NCBI Official Synonym Symbols:GRO2; GROb; MIP2; MIP2A; SCYB2; MGSA-b; MIP-2a; CINC-2a��
NCBI Protein Information:C-X-C motif chemokine 2
UniProt Protein Name:C-X-C motif chemokine 2
UniProt Synonym Protein Names:Growth-regulated protein beta; Gro-beta
Protein Family:C-X-C motif chemokine
UniProt Gene Name:CXCL2��
UniProt Entry Name:CXCL2_HUMAN
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