Human GRB2 Recombinant Protein (RPPB5889)

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SKU:
RPPB5889
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P62993

Description

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Product Name:Human GRB2 Recombinant Protein
Product Code:RPPB5889
Size:25µg
Species:Human
Target:GRB2
Synonyms:ASH, Grb3-3, MST084, MSTP084, EGFRBP-GRB2, GRB2, Growth factor receptor-bound protein 2, Adapter protein GRB2, SH2/SH3 adapter GRB2, Protein Ash.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The GRB2 protein solution contains 20mM Tris-HCl, pH-8 and 30% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EDGELGFRRG DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV

GRB2 is widely expressed and binds the EGFR and contains one SH2 domain and two SH3 domains which form a complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. GRB2 is related to the Sem5 gene of C.elegans, which is takes part in the signal transduction pathway. GRB2 is an adaptor protein that provides an important link between cell surface growth factor receptors and the Ras signaling pathway. Inhibition of GRB2 activity damages developmental processes in a variety of organisms and blocks transformation and proliferation of different cell types.

GRB2 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 237 amino acids (1-217 a.a.) and having a molecular mass of 27 kDa.GRB2 is expressed with a 20 amino acid His tag at N-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
NCBI Summary:The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P62993
NCBI GenInfo Identifier:51702266
NCBI Gene ID:2885
NCBI Accession:P62993.1
UniProt Secondary Accession:P62993,P29354, Q14450, Q63057, Q63059,
UniProt Related Accession:P62993
Molecular Weight:20,557 Da
NCBI Full Name:Growth factor receptor-bound protein 2
NCBI Synonym Full Names:growth factor receptor bound protein 2
NCBI Official Symbol:GRB2��
NCBI Official Synonym Symbols:ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2��
NCBI Protein Information:growth factor receptor-bound protein 2
UniProt Protein Name:Growth factor receptor-bound protein 2
UniProt Synonym Protein Names:Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2
Protein Family:Growth factor receptor-bound protein
UniProt Gene Name:GRB2��
UniProt Entry Name:GRB2_HUMAN
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