Enzymes Recombinant Proteins
Human GPD1 Recombinant Protein (RPPB1730)
- SKU:
- RPPB1730
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P21695
- Research Area:
- Enzymes
Description
| Product Name: | Human GPD1 Recombinant Protein |
| Product Code: | RPPB1730 |
| Size: | 25µg |
| Species: | Human |
| Target: | GPD1 |
| Synonyms: | EC 1.1.1.8, Glycerol-3-phosphate dehydrogenase [NAD+], GPDH-C, GPD-C, GPD1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The GPD1 protein solution contains 20mM Tris-HCl pH-8, and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MASKKVCIVG SGNWGSAIAK IVGGNAAQLA QFDPRVTMWV FEEDIGGKKL TEIINTQHEN VKYLPGHKLP PNVVAVPDVV QAAEDADILI FVVPHQFIGK ICDQLKGHLK ANATGISLIK GVDEGPNGLK LISEVIGERL GIPMSVLMGA NIASEVADEK FCETTIGCKD PAQGQLLKEL MQTPNFRITV VQEVDTVEIC GALKNVVAVG AGFCDGLGFG DNTKAAVIRL GLMEMIAFAK LFCSGPVSSA TFLESCGVAD LITTCYGGRN RKVAEAFART GKSIEQLEKE LLNGQKLQGP ETARELYSIL QHKGLVDKFP LFMAVYKVCY EGQPVGEFIH CLQNHPEHM |
GPD1 enzyme catalyzes the reduction of dihydroxyacetone phosphate to sn-glycerol 3-phosphate. (sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH) previous names for glycerol-3-phosphate dehydrogenase include alpha glycerol-3-phosphate dehydrogenase and glycerolphosphate dehydrogenase. However, GPD1 differs from glyceraldehyde 3-phosphate dehydrogenase (GAPDH) whose substrate is an aldehyde not an alcohol.
GPD1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 349 amino acids (1-349 a.a.) and having a molecular mass of 37.5 kDa. The GPD1 is purified by conventional chromatography.
| UniProt Protein Function: | GPD1: Defects in GPD1 are a cause of hypertriglyceridemia, transient infantile (HTGTI). An autosomal recessive disorder characterized by onset of moderate to severe transient hypertriglyceridemia in infancy that normalizes with age. The hypertriglyceridemia is associated with hepatomegaly, moderately elevated transaminases, persistent fatty liver, and the development of hepatic fibrosis. Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. |
| UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.1.1.8; Lipid Metabolism - glycerophospholipid Chromosomal Location of Human Ortholog: 12q13.12 Cellular Component: cytosol Molecular Function:glycerol-3-phosphate dehydrogenase (NAD+) activity Biological Process: phosphatidic acid biosynthetic process; triacylglycerol biosynthetic process Disease: Hypertriglyceridemia, Transient Infantile |
| NCBI Summary: | This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] |
| UniProt Code: | P21695 |
| NCBI GenInfo Identifier: | 134047785 |
| NCBI Gene ID: | 2819 |
| NCBI Accession: | P21695.4 |
| UniProt Secondary Accession: | P21695,Q8N1B0, F8W1L5, |
| UniProt Related Accession: | P21695 |
| Molecular Weight: | 35,140 Da |
| NCBI Full Name: | Glycerol-3-phosphate dehydrogenase |
| NCBI Synonym Full Names: | glycerol-3-phosphate dehydrogenase 1 |
| NCBI Official Symbol: | GPD1�� |
| NCBI Official Synonym Symbols: | GPD-C; HTGTI; GPDH-C�� |
| NCBI Protein Information: | glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic |
| UniProt Protein Name: | Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic |
| Protein Family: | Glycerol-3-phosphate dehydrogenase |
| UniProt Gene Name: | GPD1�� |
| UniProt Entry Name: | GPDA_HUMAN |
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