Human GPC4 Recombinant Protein (RPPB3634)

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RPPB3634

Description

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Product Name:Human GPC4 Recombinant Protein
Product Code:RPPB3634
Size:10µg
Species:Human
Target:GPC4
Synonyms:Glypican 4, Glypican Proteoglycan 4, K-glypican, DJ900E8.1(Glypican 4), glypican-4.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:GPC4 protein solution (0.25 mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.1M NaCl and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
Purity:Greaterthan 85% as determined by SDS-PAGE.
Amino Acid Sequence:MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSSSLP SNVCNDERMA AGNGNEDDCW NGKGKSRYLF AVTGNGLANQGNNPEVQVDT SKPDILILRQ IMALRVMTSK MKNAYNGNDV DFFDISDESS GEGSGSGCEY QQCPSEFDYNATDHAGKSAN EKADS

Glypican 4, also known as GPC4, is part of a family ofglycosylphosphatidylinositol (GPI)-anchored heparan sulphate proteoglycans(HSPGs) which take part in the control of cell division and growth regulation.GPC4 is broadly expressed in human tissues, including lung, kidney, heart,placenta, skeletal muscle, and pancreas. In addition, GPC4 has been shown to bepresent in astrocytes, haematopoietic-progenitor and bone-marrow-stromal cells.

GPC4 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 165 amino acids (401-529a.a) andhaving a molecular mass of 18kDa.GPC4 is fused to a 36 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:GPC4: Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system. Belongs to the glypican family.
UniProt Protein Details:

Protein type:Membrane protein, GPI anchor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: Xq26.2

Cellular Component: external side of plasma membrane; Golgi lumen; integral to plasma membrane; lysosomal lumen; nucleus; plasma membrane

Biological Process: anatomical structure morphogenesis; cell proliferation; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; glycosaminoglycan metabolic process; retinoid metabolic process

Disease: Simpson-golabi-behmel Syndrome, Type 1; Wilms Tumor 1

NCBI Summary:Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. [provided by RefSeq, Jul 2008]
UniProt Code:O75487
NCBI GenInfo Identifier:30923161
NCBI Gene ID:2239
NCBI Accession:O75487.4
UniProt Secondary Accession:O75487,Q6ZMA6, Q96L43, Q9NU08, Q9UJN1, Q9UPD9, B2R6J7 B4E2C0,
UniProt Related Accession:O75487
Molecular Weight:62kDa
NCBI Full Name:Glypican-4
NCBI Synonym Full Names:glypican 4
NCBI Official Symbol:GPC4��
NCBI Official Synonym Symbols:K-glypican��
NCBI Protein Information:glypican-4
UniProt Protein Name:Glypican-4
UniProt Synonym Protein Names:K-glypican
Protein Family:Glypican
UniProt Gene Name:GPC4��
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O75487
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