Human GPC4 511 aa Recombinant Protein (RPPB3635)
- SKU:
- RPPB3635
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O75487
Description
| Product Name: | Human GPC4 511 aa Recombinant Protein |
| Product Code: | RPPB3635 |
| Size: | 10µg |
| Species: | Human |
| Target: | GPC4 511 aa |
| Synonyms: | Glypican 4, Glypican Proteoglycan 4, K-glypican, DJ900E8.1 (Glypican 4), glypican-4. |
| Source: | Escherichia Coli |
| Physical Appearance: | Filtered colorless solution. |
| Formulation: | Glypican-4 filtered (0.4�m) solution at a concentration of 0.2mg/ml in 20mM Tris buffer, 50mM NaCl, pH 8.0 and 5mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MKHHHHHHASALLAAELKSK SCSEVRRLYV SKGFNKNDAP LHEINGDHLK ICPQGSTCCS QEMEEKYSLQ SKDDFKSVVS EQCNHLQAVF ASRYKKFDEF FKELLENAEK SLNDMFVKTY GHLYMQNSEL FKDLFVELKR YYVVGNVNLE EMLNDFWARL LERMFRLVNS QYHFTDEYLE CVSKYTEQLK PFGDVPRKLK LQVTRAFVAA RTFAQGLAVA GDVVSKVSVV NPTAQCTHAL LKMIYCSHCR GLVTVKPCYN YCSNIMRGCL ANQGDLDFEW NNFIDAMLMV AERLEGPFNI ESVMDPIDVK ISDAIMNMQD NSVQVSQKVF QGCGPPKPLP AGRISRSISE SAFSARFRPH HPEERPTTAA GTSLDRLVTD VKEKLKQAKK FWSSLPSNVC NDERMAAGNG NEDDCWNGKG KSRYLFAVTG NGLANQGNNP EVQVDTSKPD ILILRQIMAL RVMTSKMKNA YNGNDVDFFD ISDESSGEGS GSGCEYQQCP SEFDYNATDH AGKSANEKAD S |
Glypican 4, also known as GPC4, is part of a family of glycosylphosphatidylinositol (GPI)-anchored heparan sulphate proteoglycans (HSPGs) which take part in the control of cell division and growth regulation. GPC4 is broadly expressed in human tissues, including lung, kidney, heart, placenta, skeletal muscle, and pancreas. In addition, GPC4 has been shown to be present in astrocytes, haematopoietic-progenitor and bone-marrow-stromal cells.
Glypican-4 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (Ala19-Ser529) containing 521 amino acids including a 10 aa His tag at N-terminus. The total calculated molecular mass is 58.7kDa.
| UniProt Protein Function: | GPC4: Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system. Belongs to the glypican family. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: Xq26.2 Cellular Component: external side of plasma membrane; Golgi lumen; integral to plasma membrane; lysosomal lumen; nucleus; plasma membrane Biological Process: anatomical structure morphogenesis; cell proliferation; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; glycosaminoglycan metabolic process; retinoid metabolic process Disease: Simpson-golabi-behmel Syndrome, Type 1; Wilms Tumor 1 |
| NCBI Summary: | Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75487 |
| NCBI GenInfo Identifier: | 30923161 |
| NCBI Gene ID: | 2239 |
| NCBI Accession: | O75487.4 |
| UniProt Secondary Accession: | O75487,Q6ZMA6, Q96L43, Q9NU08, Q9UJN1, Q9UPD9, B2R6J7 B4E2C0, |
| UniProt Related Accession: | O75487 |
| Molecular Weight: | 62kDa |
| NCBI Full Name: | Glypican-4 |
| NCBI Synonym Full Names: | glypican 4 |
| NCBI Official Symbol: | GPC4�� |
| NCBI Official Synonym Symbols: | K-glypican�� |
| NCBI Protein Information: | glypican-4 |
| UniProt Protein Name: | Glypican-4 |
| UniProt Synonym Protein Names: | K-glypican |
| Protein Family: | Glypican |
| UniProt Gene Name: | GPC4�� |
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