Human GNB2L1 Recombinant Protein (RPPB3617)
- SKU:
- RPPB3617
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P63244
Description
| Product Name: | Human GNB2L1 Recombinant Protein |
| Product Code: | RPPB3617 |
| Size: | 10µg |
| Species: | Human |
| Target: | GNB2L1 |
| Synonyms: | Guanine nucleotide binding protein (G protein) beta polypeptide 2-like 1, RACK1, Receptor for Activated C Kinase 1, Gnb2-rs1, H12.3, Cell proliferation-inducing gene 21 protein, Guanine nucleotide-binding protein subunit beta-like protein 12.3, Human lung cancer oncogene 7 protein, Receptor of activated protein kinase C 1, HLC-7, PIG21, proliferation-inducing gene 21, protein homologous to chicken B complex protein guanine nucleotide binding. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The GNB2L1 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl, 5mM DTT and 50% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MTEQMTLRGT LKGHNGWVTQ IATTPQFPDM ILSASRDKTI IMWKLTRDET NYGIPQRALR GHSHFVSDVV ISSDGQFALS GSWDGTLRLW DLTTGTTTRR FVGHTKDVLS VAFSSDNRQI VSGSRDKTIK LWNTLGVCKY TVQDESHSEW VSCVRFSPNS SNPIIVSCGW DKLVKVWNLA NCKLKTNHIG HTGYLNTVTV SPDGSLCASG GKDGQAMLWD LNEGKHLYTL DGGDIINALC FSPNRYWLCA ATGPSIKIWD LEGKIIVDEL KQEVISTSSK AEPPQCTSLA WSADGQTLFA GYTDNLVRVW QVTIGTR |
GNB2L1 was first known as an anchoring protein for protein kinase C beta (PKCbeta), which it stabilizes in the active state and anchors to membranes or functional sites. But, there is now confirmation that GNB2L1 has an essential part of in critical biological responses. GNB2L1 binds specifically to the active form of PKCbeta isoforms and cooperates with numerous other vital signaling proteins such as the androgen receptor, the Src kinase family, integrin beta1, integrin beta2, integrin beta3 and integrin beta5, beta-spectrin and dynamin, RasGAP, IGF-1r, Epstein-Barr virus trans-activator protein BZLF1, p73 and pRB. GNB2L1 is highly expressed in tissues of higher mammals and humans including spleen, liver and brain.
GNB2L1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 337 amino acids (1-317 and having a molecular mass of 37.2kDa.GNB2L1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:23636399). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (PubMed:28132843). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (PubMed:19674157). Promotes migration of breast carcinoma cells by binding to and activating RHOA (PubMed:20499158). |
| UniProt Code: | P63244 |
| NCBI GenInfo Identifier: | 54037168 |
| NCBI Gene ID: | 10399 |
| NCBI Accession: | P63244.3 |
| UniProt Secondary Accession: | P63244,P25388, P99049, Q53HU2, Q5J8M6, Q5VLR4, Q6FH47 B3KTJ0, D3DWS0, |
| UniProt Related Accession: | P63244 |
| Molecular Weight: | 35,077 Da |
| NCBI Full Name: | Receptor of activated protein C kinase 1 |
| NCBI Synonym Full Names: | receptor for activated C kinase 1 |
| NCBI Official Symbol: | RACK1�� |
| NCBI Official Synonym Symbols: | H12.3; HLC-7; PIG21; GNB2L1; Gnb2-rs1�� |
| NCBI Protein Information: | receptor of activated protein C kinase 1 |
| UniProt Protein Name: | Receptor of activated protein C kinase 1 |
| UniProt Synonym Protein Names: | Receptor of activated protein C kinase 1, N-terminally processedAlternative name(s):Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed |
| UniProt Gene Name: | RACK1�� |
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