Human GNAI2 Recombinant Protein (RPPB3614)

(No reviews yet) Write a Review
SKU:
RPPB3614
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P04899

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human GNAI2 Recombinant Protein
Product Code:RPPB3614
Size:20µg
Species:Human
Target:GNAI2
Synonyms:Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting Activity Polypeptide 2, GTP-Binding Regulatory Protein Gi Alpha-2 Chain, Guanine Nucleotide-Binding Protein G(I), Alpha-2 Subunit, Adenylate Cyclase-Inhibiting G Alpha Protein, GNAI2B, H_LUCA16.1, GIP.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The GNAI2 solution�contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGCTVSAEDK AAAERSKMID KNLREDGEKA AREVKLLLLG AGESGKSTIV KQMKIIHEDG YSEEECRQYR AVVYSNTIQS IMAIVKAMGN LQIDFADPSR ADDARQLFAL SCTAEEQGVL PDDLSGVIRR LWADHGVQAC FGRSREYQLN DSAAYYLNDL ERIAQSDYIP TQQDVLRTRV KTTGIVETHF TFKDLHFKMF DVGGQRSERK KWIHCFEGVT AIIFCVALSA YDLVLAEDEE MNRMHESMKL FDSICNNKWF TDTSIILFLN KKDLFEEKIT HSPLTICFPE YTGANKYDEA ASYIQSKFED LNKRKDTKEI YTHFTCATDT KNVQFVFDAV TDVIIKNNLK DCGLF

GNAI2 is an alpha subunit of guanine nucleotide binding proteins (G proteins) and holds a guanine nucleotide binding site. GNAI2 takes part in the hormonal regulation of adenylate cyclase. GNAI2 has varies transcript variants encoding different isoforms yet only two full-length isoforms were identified up to date.

GNAI2 Human Recombinant produced in E. coli is a single polypeptide chain containing 375 amino acids (1-355) and having a molecular mass of 42.0 kDa.GNAI2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:G-alpha i2: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. Belongs to the G-alpha family. G(i/o/t/z) subfamily. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z))

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: nucleoplasm; centrosome; membrane; cytoplasm; plasma membrane; heterotrimeric G-protein complex; midbody; cytosol; vesicle; lipid raft

Molecular Function:GTPase activity; signal transducer activity; protein binding; G-protein-coupled receptor binding; GTP binding; metal ion binding; G-protein beta/gamma-subunit binding

Biological Process: platelet activation; acetylcholine receptor signaling, muscarinic pathway; activation of MAPKK activity; metabolic process; negative regulation of adenylate cyclase activity; regulation of calcium ion transport; cell cycle; signal transduction; negative regulation of synaptic transmission; G-protein coupled receptor protein signaling pathway; synaptic transmission; cell proliferation; cell division; positive regulation of cell proliferation; G-protein signaling, adenylate cyclase inhibiting pathway; blood coagulation; adenosine receptor signaling pathway; gamma-aminobutyric acid signaling pathway; response to nutrient

Disease: Ventricular Tachycardia, Familial

NCBI Summary:The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
UniProt Code:P04899
NCBI GenInfo Identifier:121023
NCBI Gene ID:2771
NCBI Accession:P04899.3
UniProt Secondary Accession:P04899,Q6B6N3, Q8IZ71, B3KTZ0, B4DYA0, B4E2X5,
UniProt Related Accession:P04899
Molecular Weight:355
NCBI Full Name:Guanine nucleotide-binding protein G(i) subunit alpha-2
NCBI Synonym Full Names:guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
NCBI Official Symbol:GNAI2��
NCBI Official Synonym Symbols:GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1��
NCBI Protein Information:guanine nucleotide-binding protein G(i) subunit alpha-2; guanine nucleotide-binding protein G(i) subunit alpha-2; adenylate cyclase-inhibiting G alpha protein; GTP-binding regulatory protein Gi alpha-2 chain; guanine nucleotide-binding protein G(i), alpha
UniProt Protein Name:Guanine nucleotide-binding protein G(i) subunit alpha-2
UniProt Synonym Protein Names:Adenylate cyclase-inhibiting G alpha protein
UniProt Gene Name:GNAI2��
UniProt Entry Name:GNAI2_HUMAN
View AllClose

0 Reviews

View AllClose

Related Products