Human GM-CSF Polyclonal Antibody
- SKU:
- CAB22109
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | Human GM-CSF Polyclonal Antibody |
| Product Code: | CAB22109 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | HuT 78 |
| Cellular Location: | extracellular region, extracellular space |
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. This gene plays a role in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been detected in SARS-CoV-2 infected patients that develop acute respiratory distress syndrome. Mice deficient in this gene or its receptor develop pulmonary alveolar proteinosis.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-144 of human Human GM-CSF (NP_000749.2). |
| Sequence: | APARS PSPST QPWEH VNAIQ EARRL LNLSR DTAAE MNETV EVISE MFDLQ EPTCL QTRLE LYKQG LRGSL TKLKG PLTMM ASHYK QHCPP TPETS CATQI ITFES FKENL KDFLL VIPFD CWEPV QE |
| Synonyms: | CSF, GMCSF |
| Calculated MW: | 16kDa |
| Observed MW: | 22kDa |
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