Enzymes Recombinant Proteins

Human GLYAT Recombinant Protein (RPPB5815)

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SKU:
RPPB5815
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q6IB77
Research Area:
Enzymes

Description

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Product Name:Human GLYAT Recombinant Protein
Product Code:RPPB5815
Size:10µg
Species:Human
Target:GLYAT
Synonyms:Glycine-N-acyltransferase, ACGNAT, GAT, CAT, AAc, HRP-1(CLP), Acyl-CoA: glycine amino acid N-acyltransferase, EC 2.3.1.13.
Source:Escherichia Coli
Physical Appearance:GLYAT is supplied as a sterile filtered clear solution.
Formulation:GLYAT protein (0.5mg/ml) is supplied in 20mM Tris-HCl, pH-8, 1mM DTT and 20% Glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MMLPLQGAQM LQMLEKSLRK SLPASLKVYG TVFHINHGNP FNLKAVVDKW PDFNTVVVCP QEQDMTDDLD HYTNTYQIYS KDPQNCQEFL GSPELINWKQ HLQIQSSQPS LNEAIQNLAA IKSFKVKQTQ RILYMAAETA KELTPFLLKS KILSPSGGKP KAINQEMFKL SSMDVTHAHL VNKFWHFGGN ERSQRFIERC IQTFPTCCLL GPEGTPVCWD LMDQTGEMRM AGTLPEYRLH GLVTYVIYSH AQKLGKLGFP VYSHVDYSNE AMQKMSYTLQ HVPIPRSWNQ WNCVPL

GLYAT is a mitochondrial acyltransferase that conjugates glycine with acyl-CoA substrates in the mitochondria. GLYAT is vital to the detoxification of endogenous and xenobiotic acyl-CoA's.

GLYAT Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 316 amino acids (1-296) and having a molecular mass of 36.0 kDa.The GLYAT is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:GLYAT: Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid. Belongs to the glycine N-acyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 2.3.1.71; Transferase; Mitochondrial; EC 2.3.1.13

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: mitochondrial matrix; mitochondrion

Molecular Function:glycine N-benzoyltransferase activity; protein binding; transferase activity, transferring acyl groups

Biological Process: acyl-CoA metabolic process; glycine metabolic process; monocarboxylic acid metabolic process; xenobiotic metabolic process

NCBI Summary:The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA's. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q6IB77
NCBI GenInfo Identifier:311033446
NCBI Gene ID:10249
NCBI Accession:Q6IB77.3
UniProt Secondary Accession:Q6IB77,O14833, Q96QK7,
UniProt Related Accession:Q6IB77
Molecular Weight:18,506 Da
NCBI Full Name:Glycine N-acyltransferase
NCBI Synonym Full Names:glycine-N-acyltransferase
NCBI Official Symbol:GLYAT��
NCBI Official Synonym Symbols:CAT; GAT; ACGNAT��
NCBI Protein Information:glycine N-acyltransferase
UniProt Protein Name:Glycine N-acyltransferase
UniProt Synonym Protein Names:Acyl-CoA:glycine N-acyltransferase; AAc; Aralkyl acyl-CoA N-acyltransferase; Aralkyl acyl-CoA:amino acid N-acyltransferase; Benzoyl-coenzyme A:glycine N-acyltransferase; Glycine N-benzoyltransferase (EC:2.3.1.71
Protein Family:Glycine N-acyltransferase
UniProt Gene Name:GLYAT��
UniProt Entry Name:GLYAT_HUMAN
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