Human GLUT6/SLC2A6 Recombinant Protein (GST,His tag)

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SKU:
RPES5571
Product Type:
Recombinant Protein
Species:
Human

Description

Product Name:Human GLUT6/SLC2A6 Recombinant Protein (GST,His tag)
Product Code:RPES5571
Size:20µg
Species:Human
Expression Host:E.coli
Synonyms:Solute carrier family 2, facilitated glucose transporter member 6, SLC2A6, Glucose transporter type 6, GLUT6
Mol Mass:33.03 kDa
AP Mol Mass:35 kDa
Tag:N-GST & C-His
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin Level:Please contact us for more information.
Bio Activity:Testing in progress
Sequence:Asn 216-Thr 289
Accession:Q9UGQ3-1
Storage:Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution:Please refer to the printed manual for detailed information.
Background:GLUT6 as a functionally uncharacterized transporter that putatively works in inflammatory responses. Inflammatory stimuli increase GLUT6 expression level, although GLUT6-knockout mice exhibit a subtle phenotype to lipopolysaccharide administration. Metabolomics and in vitro analyses show that GLUT6 functions as a glycolysis modulator in inflammatory macrophages. GLUT6 does not mediate glucose uptake and is localized on lysosomal membranes. We conclude that GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates inflammatory responses by affecting the metabolic shift in macrophages.
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