Human GKN1 Recombinant Protein (RPPB3598)

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SKU:
RPPB3598
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NS71

Description

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Product Name:Human GKN1 Recombinant Protein
Product Code:RPPB3598
Size:10µg
Species:Human
Target:GKN1
Synonyms:BRICHOS domain containing 1, 18 kDa antrum mucosa protein, gastrokine 1, Protein CA11, AMP-18, BRICD1, foveolin, FOV.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The GKN1 solution (0.25mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 1mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSH MLAYSS VHCFREDKMK FTIVFAGLLG VFLAPALANY NINVNDDNNN AGSGQQSVSV NNEHNVANVD NNNGWDSWNS IWDYGNGFAA TRLFQKKTCI VHKMNKEVMP SIQSLDALVK EKKLQGKGPG GPPPKGLMYS VNPNKVDDLS KFGKNIANMC RGIPTYMAEE MQEASLFFYS GTCYTTSVLW IVDISFCGDT VEN

Gastrokine-1 (GKN1) is a member of the gastrokine family. GKN1 has mitogenic activity and is involved in preserving the integrity of the gastric mucosal epithelium. GKN1 is down-regulated in human gastric cancer tissue in comparison to normal gastric mucosa. GKN1 is expressed in the stomach; however no expression is detected in cancer tissue or gastric cancer cell lines.

GKN1 Human Recombinant produced in E. coli is a single polypeptide chain containing 223 amino acids (1-199) and having a molecular mass of 24.5 kDa.GKN1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:GKN1: Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. Belongs to the gastrokine family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 2p13.3

Cellular Component: extracellular space

Biological Process: regulation of cell proliferation

NCBI Summary:The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NS71
NCBI GenInfo Identifier:223590223
NCBI Gene ID:56287
NCBI Accession:Q9NS71.3
UniProt Secondary Accession:Q9NS71,Q8IUA9,
UniProt Related Accession:Q9NS71
Molecular Weight:21,999 Da
NCBI Full Name:Gastrokine-1
NCBI Synonym Full Names:gastrokine 1
NCBI Official Symbol:GKN1��
NCBI Official Synonym Symbols:FOV; CA11; AMP18; BRICD1; foveolin��
NCBI Protein Information:gastrokine-1
UniProt Protein Name:Gastrokine-1
UniProt Synonym Protein Names:18 kDa antrum mucosa protein; AMP-18; Protein CA11
Protein Family:Gastrokine
UniProt Gene Name:GKN1��
UniProt Entry Name:GKN1_HUMAN
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