Human GKN1 Recombinant Protein (RPPB3598)
- SKU:
- RPPB3598
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9NS71
Description
| Product Name: | Human GKN1 Recombinant Protein |
| Product Code: | RPPB3598 |
| Size: | 10µg |
| Species: | Human |
| Target: | GKN1 |
| Synonyms: | BRICHOS domain containing 1, 18 kDa antrum mucosa protein, gastrokine 1, Protein CA11, AMP-18, BRICD1, foveolin, FOV. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The GKN1 solution (0.25mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSH MLAYSS VHCFREDKMK FTIVFAGLLG VFLAPALANY NINVNDDNNN AGSGQQSVSV NNEHNVANVD NNNGWDSWNS IWDYGNGFAA TRLFQKKTCI VHKMNKEVMP SIQSLDALVK EKKLQGKGPG GPPPKGLMYS VNPNKVDDLS KFGKNIANMC RGIPTYMAEE MQEASLFFYS GTCYTTSVLW IVDISFCGDT VEN |
Gastrokine-1 (GKN1) is a member of the gastrokine family. GKN1 has mitogenic activity and is involved in preserving the integrity of the gastric mucosal epithelium. GKN1 is down-regulated in human gastric cancer tissue in comparison to normal gastric mucosa. GKN1 is expressed in the stomach; however no expression is detected in cancer tissue or gastric cancer cell lines.
GKN1 Human Recombinant produced in E. coli is a single polypeptide chain containing 223 amino acids (1-199) and having a molecular mass of 24.5 kDa.GKN1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GKN1: Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium. Belongs to the gastrokine family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 2p13.3 Cellular Component: extracellular space Biological Process: regulation of cell proliferation |
| NCBI Summary: | The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NS71 |
| NCBI GenInfo Identifier: | 223590223 |
| NCBI Gene ID: | 56287 |
| NCBI Accession: | Q9NS71.3 |
| UniProt Secondary Accession: | Q9NS71,Q8IUA9, |
| UniProt Related Accession: | Q9NS71 |
| Molecular Weight: | 21,999 Da |
| NCBI Full Name: | Gastrokine-1 |
| NCBI Synonym Full Names: | gastrokine 1 |
| NCBI Official Symbol: | GKN1�� |
| NCBI Official Synonym Symbols: | FOV; CA11; AMP18; BRICD1; foveolin�� |
| NCBI Protein Information: | gastrokine-1 |
| UniProt Protein Name: | Gastrokine-1 |
| UniProt Synonym Protein Names: | 18 kDa antrum mucosa protein; AMP-18; Protein CA11 |
| Protein Family: | Gastrokine |
| UniProt Gene Name: | GKN1�� |
| UniProt Entry Name: | GKN1_HUMAN |
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